Results 91 to 100 of about 4,840,438 (270)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Fractional integral inequalities and error estimates of generalized mean differences

Alexandria Engineering Journal
In this research, we focus on a novel class of mean inequalities involving Riemann-Liouville fractional integrals. We employ these integrals to investigate various fundamental identities that help us to explore mean inequalities.
Muhammad Samraiz, Muhammad Tanveer Ghaffar, Saima Naheed, Miguel Vivas-Cortez   +3 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

On the generalized exponential sums and their fourth power mean

Open Mathematics
The main purpose of this article is to study the calculating problem of the fourth power mean of the two-term exponential sums and provide an accurate calculating formula for utilizing analytical methods and character sums’ properties. In the meantime, a
Liu Wencong, Ning Shushu
doaj   +1 more source

The variable for the generalized confidence interval for the lognormal mean [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2008
The purpose of this paper is to propose a new variable for the generalized confidence interval method to estimate the confidence interval of the lognormal mean.
Thongkam Maiklad
doaj  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Some Generalized Pythagorean Fuzzy Bonferroni Mean Aggregation Operators with Their Application to Multiattribute Group Decision-Making

Complexity, 2017
The Pythagorean fuzzy set as an extension of the intuitionistic fuzzy set characterized by membership and nonmembership degrees has been introduced recently. Accordingly, the square sum of the membership and nonmembership degrees is a maximum of one. The
Runtong Zhang, Jun Wang, Xiaomin Zhu, Meimei Xia, Ming Yu   +4 more
doaj   +1 more source