Results 51 to 60 of about 23,384 (256)

Investigation of the Effects of Ownership Structure on Firms Value: Evidence from Tehran Stock Market [PDF]

تحقیقات مالی, 2013
Privatization advocates believe that transfer to private sector increases firm’s performance and value, business environment, and therefore economic growth and welfare improves.
Sasan Mehrani, Ahad Hoseini, Hasan Heidari, Ahmad Pouyanfar   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Comparison of Two New Robust Parameter Estimation Methods for the Power Function Distribution. [PDF]

PLoS ONE, 2016
Estimation of any probability distribution parameters is vital because imprecise and biased estimates can be misleading. In this study, we investigate a flexible power function distribution and introduced new two methods such as, probability weighted ...
Muhammad Shakeel, Muhammad Ahsan Ul Haq, Ijaz Hussain, Alaa Mohamd Abdulhamid, Muhammad Faisal   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Wrapping Generalized Laplace and Generalized Discrete Laplace Distributions

Axioms
Generalized Laplace and discrete generalized Laplace models are described and some of their properties are reviewed. For the analysis of directional data, it is natural to consider wrapped versions of these models.
Barry C. Arnold, Ashis SenGupta
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Modification of the Gompertz Distribution Based on the Class of Extended-Weibull Distributions

Journal of Statistical Theory and Applications (JSTA), 2020
This paper introduces a new four-parameter extension of the generalized Gompertz distributions. This distribution involves some well-known distributions such as extension of generalized exponential, generalized exponential, and generalized Gompertz ...
Mohammad Reza Kazemi, Ali Akbar Jafari, Saeid Tahmasebi   +2 more
doaj   +1 more source

A Method to Generate Multivariate Data with the Desired Moments [PDF]

Communications in Statistics - Simulation and Computation, 2008
We show how it is possible to generate multivariate data which has moments arbitrary close to the desired ones. They are generated as linear combinations of variables with known theoretical moments. It is shown how to derive the weights of the linear combinations in both the univariate and the multivariate setting. The use in bootstrapping is discussed
openaire   +1 more source

Generalized Autoregressive Method of Moments [PDF]

SSRN Electronic Journal, 2015
We introduce a new estimation framework which extends the Generalized Method of Moments (GMM) to settings where a subset of the parameters vary over time with unknown dynamics. To filter out the dynamic path of the time-varying parameter, we approximate the dynamics by an autoregressive process driven by the score of the local GMM criterion function ...
Creal, Drew, Koopman, Siem Jan, Lucas, André, Zamojski, Marcin   +3 more
openaire   +3 more sources