Results 51 to 60 of about 35,400 (266)
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Common Fixed Point Theorems for Nonlinear Contractive Mappings in Dislocated Metric Spaces
Abstract and Applied Analysis, 2013 In 1986, Matthews generalized Banach contraction mapping theorem in dislocated metric space that is a wider space than metric space. In this paper, we established common fixed point theorems for a class of contractive mappings.
Yijie Ren, Junlei Li, Yanrong Yu
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
L-Fuzzy fixed point results in ℱ -metric spaces with applications
Demonstratio MathematicaJleli and Samet in [On a new generalization of metric spaces, J. Fixed Point Theory Appl. 20 (2018), 128 (20 pages)] introduced the notion of ℱ -metric space as a generalization of traditional metric space and proved Banach contraction principle in the ...
Lateef Durdana
doaj +1 more source
Subordinate Semimetric Spaces and Fixed Point Theorems
Journal of Mathematics, 2018 We introduce the concept of subordinate semimetric space. Such notion includes the concept of RS-space introduced by Roldán and Shahzad; therefore the concepts of Branciari’s generalized metric space and Jleli and Samet’s generalized metric space are ...
José Villa-Morales
doaj +1 more source
Generalized metrics and generalized twistor spaces [PDF]
Mathematische Zeitschrift, 2018 typos corrected, minor changes, to appear in Math ...
openaire +2 more sources
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah +7 more
wiley +1 more source
Fixed-Point Theorems in Branciari Distance Spaces
AxiomsIn this study, the concepts of σ-Caristi maps and generalized σ-contraction maps are introduced, and fixed-point theorems for such maps are established. A generalization of Caristi’s fixed-point theorem and Banach’s contraction principle is proved.
Seong-Hoon Cho
doaj +1 more source