Results 31 to 40 of about 46,850 (248)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Optimal Dark Hole Generation via Two Deformable Mirrors with Stroke Minimization

, 2011
The past decade has seen a significant growth in research targeted at space based observatories for imaging exo-solar planets. The challenge is in designing an imaging system for high-contrast.
Belikov, Ruslan, Elwain, Michael Mc, Give'on, Amir, Groff, Tyler, Kasdin, N. Jeremy, Kay, Jason, Pueyo, Laurent   +6 more
core   +1 more source

Aberrated dark-field imaging systems [PDF]

, 2018
We study generalized dark-field imaging systems. These are a subset of linear shift-invariant optical imaging systems, that exhibit arbitrary aberrations, and for which normally-incident plane-wave input yields zero output.
Beltran, Mario A., Paganin, David M.
core   +2 more sources

Recent developments in nonregular fractional factorial designs [PDF]

, 2008
Nonregular fractional factorial designs such as Plackett-Burman designs and other orthogonal arrays are widely used in various screening experiments for their run size economy and flexibility.
Hongquan Xu, F. Phoa, W. Wong
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Aberration in qualitative multilevel designs

, 2015
Generalized Word Length Pattern (GWLP) is an important and widely-used tool for comparing fractional factorial designs. We consider qualitative factors, and we code their levels using the roots of the unity. We write the GWLP of a fraction ${\mathcal F}$
Chen, Cheng, Fabio Rapallo, Fontana, Fontana, Fontana, Fontana, Fontana, Fontana, Fries, Grömping, Katsaounis, Li, Maria Piera Rogantin, Mukerjee, Pistone, Qin, Qin, Roberto Fontana, Schoen, Suen, Tang, Xu   +22 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Design and analysis of fractional factorial experiments from the viewpoint of computational algebraic statistics

, 2010
We give an expository review of applications of computational algebraic statistics to design and analysis of fractional factorial experiments based on our recent works.
Adams W. W., Aoki S., Aoki S., Barba G., Box G. E. P., Cheng C. S., Cox D., Deng L. Y., Fontana R., Galetto F., Lang S., McCullagh P., Mukerjee R., Notari E. R., Pistone G., Pistone G., Pistone G., Sturmfels B., Wojtas W., Ye K. Q.   +19 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Indicator function and complex coding for mixed fractional factorial designs

, 2007
In a general fractional factorial design, the $n$-levels of a factor are coded by the $n$-th roots of the unity. This device allows a full generalization to mixed-level designs of the theory of the polynomial indicator function which has already been ...
Pistone, Giovanni, Rogantin, Maria Piera
core   +3 more sources