Results 101 to 110 of about 66,278 (245)
A Pretest to Differentiate Between Weak and Nearly-Weak Instrument Asymptotics [PDF]
We propose a pretest, bootstrap Kolmogorov-Smirnov test, to differentiate between weak and nearly-weak asymptotics. This is based on bootstrapping Wald Continuous Updating Estimator (CUE) based test.
Mehmet Caner
core
Advanced Science, EarlyView.This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong +6 more
wiley +1 more source
Economies of Scale in the Canadian Food Processing Industry [PDF]
Cost functions for three Canadian manufacturing agri-food sectors (meat, bakery and dairy) are estimated using provincial data from 1990 to 1999. A translog functional form is used and the concavity property is imposed locally. The Morishima substitution
Bonroy, Olivier +2 more
core +1 more source
Advanced Science, EarlyView.FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu +6 more
wiley +1 more source
Advanced Science, EarlyView.An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han +7 more
wiley +1 more source
Brain and BehaviorPurpose In the chronic phase, many stroke survivors did not regain their pre‐stroke upper limb movement capabilities. This emphasizes the crucial role of assessing motor function in patients with stroke, as it provides valuable insights into setting ...
Da‐Hye Kim +3 more
doaj +1 more source
Nonparametric Inferences on Conditional Quantile Processes [PDF]
This paper is concerned with tests of restrictions on the sample path of conditional quantile processes. These tests are tantamount to assessments of lack of fit for models of conditional quantile functions or more generally as tests of how certain ...
Chuan Goh
core
Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux
Advanced Science, EarlyView.TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang +14 more
wiley +1 more source
Testing for co-integration in vector autoregressions with non-stationary volatility [PDF]
Many key macro-economic and financial variables are characterised by permanent changes in unconditional volatility. In this paper we analyse vector autoregressions with nonstationary (unconditional) volatility of a very general form, which includes ...
A. M. Robert Taylor +2 more
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