Results 81 to 90 of about 2,693,007 (254)

The Generalized Dynamic Factor Model. One-Sided Estimation and Forecasting [PDF]

This paper proposes a new forecasting method that exploits information from a largepanel of time series. The method is based on the generalized dynamic factor model proposedin Forni, Hallin, Lippi, and Reichlin (2000), and takes advantage of the ...
Marc Hallin, Mario Forni, Lucrezia Reichlin, Marco Lippi   +3 more
core  

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Tca4rec: contrastive learning with popularity-aware asymmetric augmentation for robust sequential recommendation

Journal of Big Data
Sequential recommender systems play a pivotal role in modern recommendation scenarios by capturing users’ dynamic interests through their historical interactions.
Yanan Bai, Liji Xiao, Chongjun Xia, Kexiang Zeng, Xiaoyu Shi   +4 more
doaj   +1 more source

From Research to Returns: A Firm-Level Analysis of R&D and Productivity in the Human Health Industry

Journal of Technology Management & Innovation
In the rapidly evolving human health industry, the role of research and development (R&D) is pivotal. This study aims to investigate the relationship between R&D and labor productivity in the pharmaceutical, biotechnology, and medical device industries,
Felipe Queiroz Silva, Bernardo Pereira Cabral, Fabio Batista Mota   +2 more
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

A Comparative Analysis of the Prediction of Gas Condensate Dew Point Pressure Using Advanced Machine Learning Algorithms

Fuels
Dew point pressure (DPP) emerges as a pivotal factor crucial for forecasting reservoir dynamics regarding condensate-to-gas ratio and addressing production/completion hurdles, alongside calibrating EOS models for integrated simulation.
Thitaree Lertliangchai, Birol Dindoruk, Ligang Lu, Xi Yang, Utkarsh Sinha   +4 more
doaj   +1 more source

Import Demand Estimation and the Generalized Composite Commodity Theorem [PDF]

A frequently encountered problem in import demand estimation is how to account for competition between imports and domestic production. Traditionally, use of the Armington model has been a way to handle this problem.
Guttormsen, Atle G., Roheim, Cathy A., Kristofersson, Dadi, Asche, Frank   +3 more
core  

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Estimation Methods of Theree Parameters Discrete Generalized Exponential Distribution [PDF]

, 2010
This article presents the estimation methods of three parameters Discrete Generalized Exponential distribution. The two-parameter generalized exponential distribution was introduced by Gupta and Kundu (1999).
Akbar Ali Shah, M. Shuaib Khan, M. Aleem
core   +1 more source

Ablation‐Immune Thermal Armor Via Microstructural‐Compatibility Design for Extreme Thermal Conditions

Advanced Science, EarlyView.
This study unveils a microstructural‐compatibility design strategy that integrates reactive melt infiltration with plasma spraying to fabricate carbon fiber‐reinforced ZrC‐SiC composites. The deliberate incorporation of SiC into the ZrC coating releases heat accumulation, suppresses detrimental lamellar ZrO2 formation, and reduces residual stress. This
Hongkang Ou, Lingxiang Guo, Bing Liu, Ziyi Yi, Yuyu Zhang, Jia Sun, Qiangang Fu   +6 more
wiley   +1 more source