Results 91 to 100 of about 10,962 (248)

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Generalized confidence intervals for the ratio or difference of two means for lognormal populations with zeros

, 2006
We discuss in this article methods for analyzing lognormal data that may include zeros. Specifically, we are interested in interval estimation for the ratio or difference of the population means. We propose here two generalized pivotal (GP) approaches: a
Zhou, Xiao-Hua, Chen, Yea-Hung
core   +1 more source

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Estimation of Stroke's Motor Function Ability Using Multimodal Biomarkers and the Role of Contralesional Motor Area

Brain and Behavior
Purpose In the chronic phase, many stroke survivors did not regain their pre‐stroke upper limb movement capabilities. This emphasizes the crucial role of assessing motor function in patients with stroke, as it provides valuable insights into setting ...
Da‐Hye Kim, Gyu Hyun Kwon, Seong‐Whan Lee, Laehyun Kim   +3 more
doaj   +1 more source

Imaging Electric Polarization Switching in Multilayer Graphene

Advanced Science, EarlyView.
Domain wall sliding‐induced electric polarization switching is directly observed for the first time in multilayer graphene, enabled by a novel optical readout method. The polarization switching is realized upon application of global and local electric fields, and mechanical forces between neighboring polar domains of opposite out‐of‐plane polarizations
Zhou Zhou, Xiyao Peng, Jianfeng Bi, Jing He, Fei Xue, Jie Jiang, Huizhen Wu, Zhiwen Shi, Haoliang Qian, Toshikaze Kariyado, Sihan Zhao   +10 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Estimation and prediction of modified progressive hybrid censored data from inverted exponentiated Rayleigh distribution

In this paper, statistical inference of an inverted exponentiated Rayleigh model is studied when the failure times are obtained under a modified progressive hybrid censoring.
Wang, Liang;Wu, Shuo-Jye;Tripathi, Yogesh Mani;Dey, Sanku
core   +2 more sources

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Applications of the Fast Double Bootstrap [PDF]

The fast double bootstrap, or FDB, is a procedure for calculating bootstrap P values that is much more computationally efficient than the double bootstrap itself. In many cases, it can provide more accurate results than ordinary bootstrap tests.
James G. MacKinnon
core  

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source