Results 71 to 80 of about 10,866 (215)

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

A Comparative Analysis of the Prediction of Gas Condensate Dew Point Pressure Using Advanced Machine Learning Algorithms

Fuels
Dew point pressure (DPP) emerges as a pivotal factor crucial for forecasting reservoir dynamics regarding condensate-to-gas ratio and addressing production/completion hurdles, alongside calibrating EOS models for integrated simulation.
Thitaree Lertliangchai, Birol Dindoruk, Ligang Lu, Xi Yang, Utkarsh Sinha   +4 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Polarization Dynamics in Ferroelectrics: Insights Enabled by Machine Learning Molecular Dynamics

Advanced Science, EarlyView.
Machine learning molecular dynamics is presented as a route to capture polarization switching, domain wall kinetics, topological polar textures, and polar mechanical coupling beyond the limits of conventional atomistic methods. This Perspective surveys recent progress and identifies key methodological directions, including long‐range electrostatics ...
Dongyu Bai, Ri He, Junxian Liu, Liangzhi Kou   +3 more
wiley   +1 more source

Unveiling the financial pathway to human development: insights from non-linear ARDL and Granger causality analysis

Humanities & Social Sciences Communications
The current study examines the relationship between financial inclusion, encompassing key indicators such as financial access, depth, efficiency, and stability, and the Human Development Index (HDI) within the BRICS economies (Brazil, Russia, India ...
Hafiz M. Sohail, Mirzat Ullah, Muhammad Shahzad Nazir, Canqing Tang   +3 more
doaj   +1 more source

Remote sensing of aboveground biomass dynamics and climatic responses in tropical lowland rainforests: Evidence from Bawangling, China

Ecological Indicators
Dynamics of tropical forests' aboveground biomass (AGB) are pivotal to the global carbon balance, yet the nonlinear and interactive mechanisms by which AGB responds to climate change in tropical lowland rainforests (TLR) remain unclear.
Yuxin Chen, Mingjiang Mao, Wenfeng Gong, Shijie Mao, Yixi Ma, Renhao Chen, Miao Wang, Xiaoxiao Zhang, Jinming Xu, Junting Jia, Peng Zhou   +10 more
doaj   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

ICT, trade, economic growth, and unemployment nexus: panel evidence from the Indian Ocean Rim Association

Research in Globalization
This study investigates the impact of Information and Communication Technology (ICT) adoption on international trade flows within the Indian Ocean Rim Association (IORA) countries by employing an augmented gravity model framework.
Laxmi Dawn, Aman Verma, Hemlata Manglani
doaj   +1 more source

Thermally Driven Supramolecular Chirality Evolution in Low‐Bandgap Fused‐Ring Conjugated Molecules for High‐Performance NIR Circularly Polarized Light Detection

Advanced Science, EarlyView.
A supramolecular chirality evolution strategy in chiral low‐bandgap fused‐ring conjugated molecules enables high‐performance near‐infrared (NIR) circularly polarized light photodetection. Halogen substitution and thermal annealing induce chiral amplification and hierarchical ordering. Integrated into Schottky barrier vertical transistors, the optimized
Jaeyong Ahn, Kwangmin Kim, Sangwook Lee, Seul Lee, SungHyun Hur, BongSoo Kim, Joon Hak Oh   +6 more
wiley   +1 more source