Results 81 to 90 of about 2,508,958 (213)

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Unveiling the financial pathway to human development: insights from non-linear ARDL and Granger causality analysis

Humanities & Social Sciences Communications
The current study examines the relationship between financial inclusion, encompassing key indicators such as financial access, depth, efficiency, and stability, and the Human Development Index (HDI) within the BRICS economies (Brazil, Russia, India ...
Hafiz M. Sohail, Mirzat Ullah, Muhammad Shahzad Nazir, Canqing Tang   +3 more
doaj   +1 more source

Remote sensing of aboveground biomass dynamics and climatic responses in tropical lowland rainforests: Evidence from Bawangling, China

Ecological Indicators
Dynamics of tropical forests' aboveground biomass (AGB) are pivotal to the global carbon balance, yet the nonlinear and interactive mechanisms by which AGB responds to climate change in tropical lowland rainforests (TLR) remain unclear.
Yuxin Chen, Mingjiang Mao, Wenfeng Gong, Shijie Mao, Yixi Ma, Renhao Chen, Miao Wang, Xiaoxiao Zhang, Jinming Xu, Junting Jia, Peng Zhou   +10 more
doaj   +1 more source

"Empirical Likelihood Methods in Econometrics: Theory and Practice" [PDF]

Recent developments in empirical likelihood (EL) methods are reviewed. First, to put the method inperspective, two interpretations of empirical likelihood are presented, one as a nonparametric maximum likelihood estimation method (NPMLE) and the other as
Yuichi Kitamura
core  

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Oracally Efficient Two-Step Estimation of Generalized Additive Model [PDF]

Generalized additive models (GAM) are multivariate nonparametric regressions for non-Gaussian responses including binary and count data. We propose a spline-backfitted kernel (SBK) estimator for the component functions.
Wolfgang Karl Härdle, Rong Liu, Lijian Yang   +2 more
core  

Penalized likelihood estimation and iterative kalman smoothing for non-gaussian dynamic regression models [PDF]

, 1995
Dynamic regression or state space models provide a flexible framework for analyzing non-Gaussian time series and longitudinal data, covering for example models for discrete longitudinal observations.
Fahrmeir, Ludwig, Wagenpfeil, Stefan
core   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

ICT, trade, economic growth, and unemployment nexus: panel evidence from the Indian Ocean Rim Association

Research in Globalization
This study investigates the impact of Information and Communication Technology (ICT) adoption on international trade flows within the Indian Ocean Rim Association (IORA) countries by employing an augmented gravity model framework.
Laxmi Dawn, Aman Verma, Hemlata Manglani
doaj   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source