Results 91 to 100 of about 2,275,501 (283)

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Partial Exposure Attacks Against a Family of RSA-like Cryptosystems

Cryptography
An RSA generalization using complex integers was introduced by Elkamchouchi, Elshenawy and Shaban in 2002. This scheme was further extended by Cotan and Teșeleanu to Galois fields of order n≥1. In this generalized framework, the key equation is ed−k(pn−1)
George Teşeleanu
doaj   +1 more source

Whitemanʼs generalized cyclotomic numbers with respect to t primes

Finite Fields and Their Applications, 2012
Let \(p_1, \dots, p_t\) be distinct primes and \(\gcd(p_i -1, p_j-1) =2\) if \(i\neq j\). Let \(g\) be the common primitive root among \(v= p_1\cdots p_t\) and \(d := \mathrm{ord}_v(g)\). The Whiteman's subgroup \(W^{(t)} = (g)\) is a subgroup of the multiplicative group \(\mathbb{Z}_{v}^*\) of order \(d\) (therefore the index is \(2^{t-1}\)).
Jing Cao, Qin Yue 0001, Liqin Hu
openaire   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

On Discrete Shifts of Some Beurling Zeta Functions

Mathematics
We consider the Beurling zeta function ζP(s), s=σ+it, of the system of generalized prime numbers P with generalized integers m satisfying the condition ∑m⩽x1=ax+O(xδ), a>0, 0⩽δσP with some σP0, there exists a closed non-empty set of analytic functions ...
Antanas Laurinčikas, Darius Šiaučiūnas   +1 more
doaj   +1 more source

Prime Faux Pas

, 2008
There have been many conjectures made about prime numbers. We will look at a few of the major conjectures, examine why they were thought to be true, and prove why they are ...
Seitz, Amanda, Jensen, Ph.D., Jacqueline
core  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

On Joint Approximation of Analytic Functions by Beurling Zeta-Functions

Mathematics
For j=1,…,r, let Pj be a system of generalized prime numbers, NPj the corresponding system of generalized integers, and ζPj(s), s=σ+it, the Beurling zeta-function. In the paper, we consider simultaneous approximation of a collection of analytic functions
Andrius Geštautas, Antanas Laurinčikas, Darius Šiaučiūnas   +2 more
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

A question of Erdős and Graham on Egyptian fractions

Discrete Analysis
A question of Erdős and Graham on Egyptian fractions, Discrete Analysis 2025:28, 13 pp. An _Egyptian fraction_ is a way of writing a rational number as a sum of reciprocals of positive integers with distinct denominators.
David Conlon, Jacob Fox, Xiaoyu He, Dhruv Mubayi, Huy Tuan Pham, Andrew Suk, Jacques Verstraëte   +6 more
doaj   +1 more source