Results 41 to 50 of about 2,275,501 (283)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
On Value Distribution of Certain Beurling Zeta-Functions
MathematicsIn this paper, the approximation of analytic functions by shifts ζP(s+iτ) of Beurling zeta-functions ζP(s) of certain systems P of generalized prime numbers is discussed. It is required that the system of generalized integers NP generated by P satisfies ∑
Antanas Laurinčikas
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Subsets of prime numbers received by means of generalized arithmetic progression
Дифференциальная геометрия многообразий фигур, 2018 A short historical information about formulas and polynomials generating subsets of prime numbers is given. Examples of subsets of prime numbers by using generalized arithmetic progression are obtained.
V. Malakhovsky
doaj
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
POLYNOMIAL PATTERNS IN THE PRIMES
Forum of Mathematics, Pi, 2018 Let $P_{1},\ldots ,P_{k}:\mathbb{Z}\rightarrow \mathbb{Z}$ be polynomials of degree at most ...
TERENCE TAO, TAMAR ZIEGLER
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Extension Functors of Generalized Local Cohomology Modules
پژوهشهای ریاضی, 2021 Introduction Throughout this paper, is a commutative Noetherian ring with non-zero identity, is an ideal of , is a finitely generated -module, and is an arbitrary -module which is not necessarily finitely generated.
Alireza Vahidi +2 more
doaj
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source