Results 141 to 150 of about 22,085 (238)

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

A high-gain symmetric-bipolar buck-boost AC-AC converter with step-changed output frequency and rectifier operation. [PDF]

Sci Rep
Karimi Hajiabadi M, Mosallanejad A, Salemnia A, Lahooti Eshkevari A.   +3 more
europepmc   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

Inverse design of cellular structures with the targeted nonlinear mechanical response. [PDF]

Sci Rep
Nakarmi S, Daphalapurkar NP, Lee KS, Kim J, Leiding JA, Dattelbaum DM, Luscher DJ.   +6 more
europepmc   +1 more source

Graphene Aerogels With Spherical Pore Structure for Broad Frequency Regulation and Enhanced Low‐Frequency Response

Advanced Science, EarlyView.
A graphene aerogel with a spherical‐pore structure is constructed via microbubble templating. This unique architecture suppresses strain‐induced percolation of conductive networks, enabling dynamic frequency tuning. It also delivers enhanced low‐frequency absorption with an effective absorption bandwidth of 2.56 GHz, covering 91% of the low‐frequency ...
Liang Li, Jiale Yan, Gengping Wan, Changlong Du, Yubing Lv, Yongzhu Yan, Zhaoyang Li, Guizhen Wang   +7 more
wiley   +1 more source

ST-GICM: A Spatiotemporal Graph Learning Framework with Intrinsic Curiosity for Robust Autonomous Exploration. [PDF]

Sensors (Basel)
He L, Liu W, Li W.
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Integrated analysis of fossils and molecular divergence time estimates a latest Jurassic origin of angiosperms. [PDF]

Nat Plants
Wu R, Álvarez-Carretero S, Tong Y, Wan S, Schneider H, Clark J, Pisani D, Silvestro D, Donoghue PCJ.   +8 more
europepmc   +1 more source

Fuzzy Soft Generalized Closed Sets in Fuzzy Soft Topological Spaces

International Journal of Applied Engineering Research, 2019
Anil P Narappanavar, Zeba Tarrannum
openaire   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source