Results 81 to 90 of about 517,995 (264)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Generalized Chromatic Functions

International Mathematics Research Notices
Abstract We define vertex-colourings for edge-partitioned digraphs, which unify the theory of $P$-partitions and proper vertex-colourings of graphs. We use our vertex-colourings to define generalized chromatic functions, which merge the chromatic symmetric and quasisymmetric functions of graphs and generating functions of $P$-partitions.
Aliniaeifard, Farid, Li, Shu Xiao, van Willigenburg, Stephanie   +2 more
openaire   +3 more sources

Generalized Kiesswetter's Functions

Real Analysis Exchange, 2015
In 1966, Kiesswetter found an interesting example of continuous everywhere but differentiable nowhere functions using base-4 expansion of real numbers. In this paper we show how Kiesswetter’s function can be extended to general cases. We also provide an equivalent form for such functions via a recurrence relation.
Li, Delong, Miao, Jie
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

On the sum of partition norms and its connection to norms of partitions with parts greater than one [PDF]

Notes on Number Theory and Discrete Mathematics
We study the —the product of the parts of a partition—with emphasis on partitions whose parts all exceed 1. We obtain two bivariate recurrences for the sum of norms over partitions into distinct parts, including a refinement that separates the ...
Meenakshi Rana, Harman Kaur, Abhimanyu Kumar   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Higher-genus Fay-like identities from meromorphic generating functions

SciPost Physics
A possible way of constructing polylogarithms on Riemann surfaces of higher genera facilitates integration kernels, which can be derived from generating functions incorporating the geometry of the surface.
Konstantin Baune, Johannes Broedel, Egor Im, Artyom Lisitsyn, Yannis Moeckli
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source