Results 251 to 260 of about 1,314,573 (305)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Association between the incidence of infusion-related reactions by obinutuzumab and the dose of corticosteroid as premedication: a multicenter retrospective cohort study. [PDF]

J Pharm Health Care Sci
Ohtsubo T, Yamamoto K, Matumoto S, Ito K, Sasa Y, Tomishima K, Dote S, Makihara K, Wakasugi Y, Mitsuie T, Yamagiwa K, Sato K, Hasegawa H, Uoshima N, Kitahiro Y, Tomogane K.   +15 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Controllable protein design via autoregressive direct coupling analysis conditioned on principal components. [PDF]

PLoS Comput Biol
Caredda F, Gennai L, De Los Rios P, Pagnani A.   +3 more
europepmc   +1 more source

Gene action studies of yield-contributing traits in groundnut (Arachis hypogaea L.) through generation mean analysis

Ellandula Anvesh, R. Kalaiyarasi, S. Ramasamy, R. Balasubramanian, D. Amirtham, M Senthivelu   +5 more
openalex   +2 more sources

RTX-family toxin EhxA drives morphological remodeling and thrombogenesis in RBCs during enterohemorrhagic <i>Escherichia coli</i> infection. [PDF]

Sci Adv
Choi S, Park H, Bae ON, Bian Y, Im H, Chung HY.   +5 more
europepmc   +1 more source

Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice. [PDF]

Aging Cell
Gulzar H, Musson R, Bisogno S, Alluhaibi L, Maximenko A, Bik E, Barańska M, Depciuch J, Ptak GE.   +8 more
europepmc   +1 more source

Antibiotic Prophylaxis Strategies and Surgical Site Infections in Colorectal Surgery: A Systematic Review and Network Meta-Analysis.

JAMA Netw Open
Motaghi S, Karam SG, Mulazzani F, Mirzayeh Fashami F, Buchan TA, Ibrahim S, Moradi Falah Langeroodi S, Khademioore S, Couban RJ, Mbuagbaw L, Mertz D, Loeb M.   +11 more
europepmc   +1 more source

Deep learning for synthetic PET imaging: a systematic mapping review of techniques, metrics, and clinical relevance. [PDF]

Eur Radiol Exp
Vaccaro M, Rosa E, Placidi E, Guarnera A, Secinaro A, Gandolfo C, Garganese MC, Napolitano A.   +7 more
europepmc   +1 more source

Storage of Euschistus heros (Fabricius, 1794) Eggs for Biological Control with Telenomus podisi Ashmead, 1851 in Open Fields in Brazil. [PDF]

Neotrop Entomol
Barreto MTS, Camarozano CT, de Melo MC, Junior AC, Gontijo LM, Takahashi TA, Parra JRP.   +6 more
europepmc   +1 more source