Results 221 to 230 of about 47,775 (306)

Age-period-cohort effect on motor neuron disease mortality in the United States, 2001-2020. [PDF]

Front Neurol
Raymond J, Larson T, Nair T, Kaufman J, Horton DK, Weisskopf M, Mohidul S, Mehta P.   +7 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Trans-Generational Morphological Trait Plasticity in Parthenogenetic Offspring of Two <i>Brachionus dorcas</i> Morphotypes Induced by <i>Asplanchna</i> Kairomones. [PDF]

Ecol Evol
Ge Y, Zhu J, Ren Y, Wu X, Zhou B, Wu Y, Ge Y.   +6 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

The Moderating Effect of Generation on the Association Between Long Working Hours and Mental Health: A Cross-Sectional Study of Korean Employees. [PDF]

Healthcare (Basel)
Jung S, An Y, Jeon SW, Kim J, Kim E, Yang JH, Cho SJ.   +6 more
europepmc   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Dopamine, Distraction, and Disruption: Perspectives on How Technology and Generation Z Are Reshaping Medical Education.

JMIR Med Educ
Andrade BB, Araújo Pereira M, Avena K.
europepmc   +1 more source

Generational trends in reproductive factors among women in the US: implications for breast cancer incidence. [PDF]

Breast Cancer Res
Yang L, Toriola AT.
europepmc   +1 more source