Results 241 to 250 of about 47,775 (306)

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Caregiver Mental Health Across Generations. [PDF]

J Fam Issues
Gallagher VT, Patterson A, Hebdon M, Manning CA, Shaffer KM.   +4 more
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Construing motherhood across generations in Taiwan's social transition: associations with depression and somatic symptoms. [PDF]

Front Psychol
Lin Y.
europepmc   +1 more source

Tax Policy and the Economy, Volume 14 [PDF]

Alan J. Auerbach, Philip Oreopoulos
core  

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Factors Associated With the Ability To Keep Up With Technology Developments: Findings From a National Multigenerational Cross-Sectional Survey in Sweden. [PDF]

JMIR Aging
Offerman J, Fristedt S, Schmidt SM, Iwarsson S.   +3 more
europepmc   +1 more source

Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study. [PDF]

Clin Epigenetics
Ciantar J, Rajić S, Kostiniuk D, Raulamo E, Kartiosuo N, Lai L, Mishra PP, Lyytikäinen LP, Kleber ME, Rovio S, Mykkänen J, Pahkala K, Peters A, Winkelmann J, März W, Kähönen M, Raitakari O, Lehtimäki T, Waldenberger M, Marttila S, Raitoharju E.   +20 more
europepmc   +1 more source

Generational effects in Down syndrome: Enriched environment enhances functionality without reducing Alzheimer's disease risk. [PDF]

Alzheimers Dement
Vaqué-Alcázar L, Videla L, Benejam B, Del Hoyo Soriano L, Barroeta I, Fernandez S, Rodríguez-Baz Í, Arriola-Infante JE, Arranz J, Maure Blesa L, Sanjuan-Hernández A, Morcillo-Nieto AO, Bejanin A, Arenaza-Urquijo EM, Lleó A, Bartrés-Faz D, Carmona-Iragui M, Fortea J.   +17 more
europepmc   +1 more source