Results 31 to 40 of about 47,775 (306)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Understanding Differences in the Dimensions of Brand Loyalty Among Generational Cohorts in the Carbonated Beverage Category

Journal of Applied Marketing Theory, 2018
This study explores generational differences in the antecedents of brand loyalty in the carbonated beverage category. Eight loyalty dimensions were examined across three generational cohorts: Millennials, Generation X and Baby Boomers.
Neleen Leslie-Piper, Petula Senior
doaj   +1 more source

Generational Cohorts and Their Collective Memories: An Empirical Study to Develop the Generational Profiling of the Pakistani Workforce

iRASD Journal of Management, 2021
The current study aims to sociologically categorize the generations of the Pakistani workforce. For this purpose, similar to Schuman and Scott (1989)’s research methodology of identifying generations on the basis of their collective memories of ...
Aliya Ahmad Shaikh, Warda Najeeb Jamal, Syed Muhammad Javed Iqbal , Qurrat Ul Ain Najeeb Jamal   +3 more
doaj   +1 more source

Changes in cohort wealth over a generation [PDF]

Demography, 1988
Abstract Empirical computation of expected wealth is hampered by two problems: mortality risks vary in the population and over time; and observation of net estates for most cohorts is truncated, as some individuals in a cohort survive the calendar date on which observation is terminated. These two problems are solved in estimating cohort
M H, David, P L, Menchik
openaire   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Do talent management strategies influence the psychological contract within a diverse environment?

SA Journal of Human Resource Management, 2018
Orientation: Even though globalisation has resulted in a more diverse workforce and working environment, talent management strategies have not evolved catering for the diversity experienced in organisations.
Paul Poisat, Michelle R. Mey, Gary Sharp
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Gold investment behaviour among Muslim generational cohorts

Asian Journal of Islamic Management
Purpose – This study examines how financial attitude, behavior, knowledge, literacy, financial socialization, and subjective norms influence individuals’ intention to invest in gold across Generations X, Y, and Z.
Achmad Rizal, Alex Fahrur Riza, Fadhilah Abudullah Asuhaimi, Adib Susilo   +3 more
doaj   +1 more source

From Boomers to Millennials: unraveling the complexities of online shopping behavior in Indonesia [PDF]

Innovative Marketing
This study examines the intricate dynamics of utilitarian browsing, hedonic browsing, electronic word of mouth (e-WOM), e-satisfaction, and e-loyalty across three generational cohorts –Millennials, Gen X, and Baby Boomers – in Indonesian online ...
Widarto Rachbini, Silverius Y. Soeharso, Harimurti Wulandjani, Muhammad Anwar Fathoni, Emi Rahmawati   +4 more
doaj   +1 more source