Results 41 to 50 of about 47,775 (306)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Lifetime Earnings Inequality in Germany [PDF]

open access: yes
This paper documents the magnitude, pattern, and evolution of lifetime earnings inequality in Germany. Based on a large sample of earning biographies from social security records, we show that the intra-generational distribution of lifetime earnings of ...
Bönke, Timm   +2 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

The generational tourist: how age cohorts influence travel product choices

open access: yesMednarodno Inovativno Poslovanje
Purpose of the article – The purpose of this article is to explore the correlation between generational values and tourism product selection. It addresses the scientific problem of how socio-historical experiences influence consumer behaviour in the ...
Mitja Gorenak   +2 more
doaj   +1 more source

The Age-shift: observations on social policy, ageism and the dynamics of the adult lifecourse [PDF]

open access: yes, 2007
Through a critical engagement with policy trends, we ask how shifts in ideologies of ageing might influence the possibilities available to adults as they grow older. Of particular interest are the implications for how people are being encouraged to think
Biggs, S   +3 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

A Conceptual Analysis of Technology Usage and Work–Family Interface Among Millennials in India

open access: yesVikalpa
Decades of studies on the work-family interface and the preponderance of literature make it rather ambiguous to find a future direction for research. While only in the past decade technology and generational cohorts have been studied concerning the work ...
Sasmita Dash
doaj   +1 more source

Alternative Protein Sources: Generation Y’s Food Neophobia, Entomophagy Acceptance, Self-Assessed Environmental Concern, and Intention to Recommend Entomophagy

open access: yesProceedings
The aim of this paper is to explore the Greek Generation Y cohorts’ food neophobia, intention to engage in entomophagy, self-assessed environmental concern, and intention to recommend entomophagy as an alternative to meat protein intake.
Irene (Eirini) Kamenidou   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Multigenerational workforce and organizational performance: A convergent analysis

open access: yesInternational Journal of Academe and Industry Research
The composition of today's workforce has experienced a notable increase in age diversity with four generations working together. The purpose of the study was to explore the influence of a multigenerational workforce on organizational performance ...
Chilufya C. Chiwisa, Mubanga Mpundu
doaj   +1 more source

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