Results 61 to 70 of about 47,775 (306)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Generational cohorts and their attitudes toward advertising

Tržište, 2013
This research is aimed at determining the attitudes with regard to advertising from the perspective of generational cohorts in Sarawak. A two-phase of study was conducted to firstly identify generational cohorts in the state and, secondly, to investigate
Ernest Cyril de Run, Hiram Ting
doaj  

Generational dichotomies in public perception of social media coverage of the Nigerian #EndSARS protests: Implication for networked communication

Cogent Arts & Humanities, 2021
There are intense debates about the presumed generational dichotomies in the use and perception of new media technologies by young people and older adults.
Joshua Aghogho Erubami, Emmanuel Ufuophu-Biri, Luke Ifeanyi Anorue, Uzoma Oluchukwu Nwabunze, Emeka S. S. Orekyeh   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Generational perspectives on the biafra emancipation movement: analyzing attitudes, beliefs, and activism across political generations in Nigeria

International Journal of Adolescence and Youth
This qualitative study explores the perspectives of the Biafran Emancipation Movement across political generational cohorts in Nigeria. Employing a qualitative phenomenological research design, the research utilized semi-structured interviews and ...
Omerebere Mariagoretti Ifeanyi
doaj   +1 more source

Overview of Characteristics and Analysis of Differences Between Generational Cohorts

Izzivi Prihodnosti, 2022
Background and Originality: The research aims to find and review the literature in the field of differentiation, work and motivation of different generational groups. We are interested in the opinions and results of various studies in individual areas of
Dušan Janežič
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A Review of Generations X and Y’ Work Values and Attitudes Across North America and Europe

Studia Universitatis Babeş-Bolyai Negotia
The Generational Theory, on the other hand, has been used uniformly in numerous studies without taking into account the historical, social, and cultural variations from one place to another.
Adina Letiția NEGRUȘA
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Generational Cohort Analysis of Sports Spectators:

Maketingu Janaru, 2022
In the U.S., there has been growth of research methods utilizing the “Generational Cohort Theory,” which proposes that people who are brought up in the same era should share the same values. However, there are only a few case studies using this segmentation method in Japan.
openaire   +3 more sources