Results 181 to 190 of about 819,389 (297)

Erratum to: Risk for Autism Across Generations. [PDF]

Biol Psychiatry
europepmc   +1 more source

Intergenerational patterns of digital use: Evidence from a large cross-sectional study. [PDF]

PLoS One
Erfani G, Steven A, Young-Murphy L, Charlton W, De Luca H, Wilson-MenzFeld G.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Impact of genomic selection for disease resistance on the spread of infection in a simulated aquaculture population. [PDF]

Genet Sel Evol
García-Ballesteros S, Fernández J, Doeschl-Wilson AB, Villanueva B.   +3 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Potential risk of heartworm infection in the United States of America and its projected incidence by 2100. [PDF]

Parasit Vectors
Morchón R, Rodríguez-Escolar I, Collado-Cuadrado M, Infante González-Mohino E, Montoya-Alonso JA, Carretón E, Balmori-de la Puente A.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Using deep learning models as a genetic architecture for the simulation of breeding schemes. [PDF]

G3 (Bethesda)
Onabanjo O, Meuwissen T, Gjøen HM, Karaman E, Chu TT, Berg P.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Generational variation and stabilization in resynthesized allotetraploid Brassica juncea derived from diploid progenitors B. rapa and B. nigra. [PDF]

BMC Plant Biol
Tripathi S, Garg P, Gupta S, Kushwaha R, Sharma J, Sharma SS, Kumari S, Kashyap A, Singh N, Yadav R, Bhattacharya R, Kumar A, Rao M.   +12 more
europepmc   +1 more source