Results 231 to 240 of about 4,829,196 (302)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Dynamic Performance Enhancement of a High‐Agility Hypersonic Mechanical System via a Learning‐Augmented Robust Control Architecture

open access: yesInternational Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT The design of control systems for high‐agility mechanical systems operating in extreme environments is a significant challenge in nonlinear dynamics. This paper addresses the complex dynamic control problem of a hypersonic interceptor, modeled as a multi‐input multi‐output (MIMO) mechanical system characterized by strong aerodynamic cross ...
Mohammad Mahdi Soori   +1 more
wiley   +1 more source

Multi‐Agent Reinforcement Learning for Joint Police Patrol and Dispatch

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT Police patrol units need to split their time between performing preventive patrol and being dispatched to serve emergency incidents. In the existing literature, patrol and dispatch decisions are often studied separately. We consider joint optimization of these two decisions to improve police operations efficiency and reduce response time to ...
Matthew Repasky, He Wang, Yao Xie
wiley   +1 more source

Interdiction Models and Heuristics for Graph Propagation

open access: yesNetworks, EarlyView.
ABSTRACT Given a graph G=(V,E)$$ G=\left(V,E\right) $$ and a set S⊂V$$ S\subset V $$ of activated/infected nodes, we consider the problem of determining the set of c$$ c $$ nodes that minimizes the network propagation on the subgraph that results from the removal of those c$$ c $$ nodes. To measure network propagation, we assume that a node i$$ i $$ is
Agostinho Agra, José Maria Samuco
wiley   +1 more source

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