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Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
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Proceedings 17th IEEE International Conference on Automated Software Engineering,, 2002
A design pattern encapsulates the knowledge of object-oriented designers into re-usable artifacts. A design pattern is a descriptive device that fosters software design re-use. There are several reasons why design patterns are not used as generative constructs that support code re-use.
Steve MacDonald +5 more
openaire +1 more source
A design pattern encapsulates the knowledge of object-oriented designers into re-usable artifacts. A design pattern is a descriptive device that fosters software design re-use. There are several reasons why design patterns are not used as generative constructs that support code re-use.
Steve MacDonald +5 more
openaire +1 more source
The design of a parser generator
Proceedings of the 16th annual Southeast regional conference on - ACM-SE 16, 1978In this paper we present an algorithm for generating bounded-context parsers using a modified version of Knuth's algorithm for generating LR(k) parsers. We also describe the internal design of a parser generating system capable of constructing the parsing tables for (s,l) bounded-context and LR(1) parsers.
David A. Workman, John B. Higdon
openaire +2 more sources
Generalized network design polyhedra [PDF]
Networks, 2011 AbstractIn recent years, there has been an increased literature on so‐called generalized network design problems (GNDPs), such as the generalized minimum spanning tree problem and the generalized traveling salesman problem. In a GNDP, the node set of a graph is partitioned into “clusters,” and the feasible solutions must contain one node from each ...
Corinne Feremans +3 more
openaire +4 more sources
General Design Classifications
Journal of the American Academy of Child & Adolescent Psychiatry, 2002This column described the general design classifications of between-groups, within-subjects, and mixed designs. Remember that in between-groups designs, each participant is in only one group or condition. In within-subjects or repeated-measures designs, on the other hand, each participant receives all the conditions or levels of the independent ...
George A, Morgan +2 more
openaire +2 more sources