Results 71 to 80 of about 271,355 (282)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Enhanced Pix2pixGAN with Spatial-Channel Attention for Underground Medium Inversion from GPR

Remote Sensing
Ground penetrating radar (GPR) data inversion, especially in parallel-layered homogeneous media with multiple subsurface targets, still faces challenges in accurately reconstructing geometric structures due to weak reflections and complex target–medium ...
Sicheng Yang, Liangshuai Guo, Yahan Yang, Hongxia Ye   +3 more
doaj   +1 more source

Towards the ontology-based approach for factual information matching [PDF]

, 2018
Factual information is information based on facts or relating to facts. The reliability of automatically extracted facts is the main problem of processing factual information.
Cherednichenko, Olga, Doroshenko, Anastsiia, Sharonova, Natalia Valeriyevna   +2 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Linguaggio, genere, media

Lingue e culture dei media
Nel contributo si inquadra brevemente, da un punto di vista storico e teorico, la riflessione linguistica sul rapporto tra lingua, linguaggio e genere, che si è aperta in Italia dopo la pubblicazione (1987) dello studio di Alma Sabatini Il sessismo nella lingua italiana.
I. Bonomi, M. Piotti, C. Robustelli
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Direct shoot regeneration from nodes of Phalaenopsis orchids

Acta Agriculturae Slovenica, 2004
Nodes with dormant buds from flower stalks of orchid Phalaenopsis sp. were plated on six culture media. The composition of the culture media affected the induction, regeneration, number and form of Phalaenopsis regenerants.
Polonca KOŠIR, Suzana ŠKOF, Zlata LUTHAR   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The Modernist Corpse: Posthumanism and the Posthumous by Erin E. Edwards [PDF]

, 2018
Review of Erin E.
Mangoutas, A. Irene
core   +1 more source