Results 121 to 130 of about 220,222 (219)

Design topological materials by reinforcement fine-tuned generative model. [PDF]

Nat Commun
Xu H, Qian D, Liu Z, Jiang Y, Wang J.
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Editorial: Machine learning and statistical models: unraveling patterns and enhancing understanding of mental disorders

Frontiers in Psychiatry
Quan Wang
doaj   +1 more source

Design of Synthesizable PROTACs through Synthesis Constrained Generative Model and Reinforcement Learning. [PDF]

JACS Au
Xu M, Huang C, Pang L, Deng Q, Zhang H, Qiao A, Luo Z, Wang Z, Hsieh CY, Zhang Z, Chen TG, Chen H, Lei J.   +12 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

HUG-VAS: A Hierarchical NURBS-Based Generative Model for Aortic Geometry Synthesis and Controllable Editing. [PDF]

Comput Methods Appl Mech Eng
Du P, Xu M, Zhu X, Wang JX.
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Predicting Single-Cell Perturbation Responses Across Biological Contexts With a Deep Generative Model Integrating Optimal Transport. [PDF]

Adv Sci (Weinh)
Wang J, Liu Z, Zhang Z, Cao Y, Ren J, Cheng P, Tian J, Xie L, Lu X, Du Z, Liu Y.   +10 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

A dependency-aware deep generative model for inferring RNA velocity from spatial transcriptomics. [PDF]

Bioinformatics
Chen S, Yu L, Jiang P, Zhang L, Tian T.
europepmc   +1 more source