Results 191 to 200 of about 212,177 (318)

Deep learning generative model for conditional crystal structure prediction of sodium amide. [PDF]

NPJ Comput Mater
Guan R, Liu A, Song Y.
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

CrystalFlow: a flow-based generative model for crystalline materials. [PDF]

Nat Commun
Luo X, Wang Z, Wang Q, Shao X, Lv J, Wang L, Wang Y, Ma Y.   +7 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

scSurv: a deep generative model for single-cell survival analysis. [PDF]

Bioinformatics
Mizukoshi C, Kojima Y, Hayashi S, Abe K, Kasugai D, Shimamura T.   +5 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Building the connectome of a small brain with a simple stochastic developmental generative model. [PDF]

Proc Natl Acad Sci U S A
Richter O, Schneidman E.
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Editorial: Machine learning and statistical models: unraveling patterns and enhancing understanding of mental disorders

Frontiers in Psychiatry
Quan Wang
doaj   +1 more source

Reaction-conditioned generative model for catalyst design and optimization with CatDRX. [PDF]

Commun Chem
Kengkanna A, Kikuchi Y, Niwa T, Ohue M.
europepmc   +1 more source