Results 291 to 300 of about 22,229,619 (357)

Generative pretrained multi-step prompting -a review a general two- phase model and future prospects

Yuval Cohen, Yehudit Aperstein
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

IEV2Mol: Molecular Generative Model Considering Protein-Ligand Interaction Energy Vectors. [PDF]

J Chem Inf Model
Ozawa M, Nakamura S, Yasuo N, Sekijima M.   +3 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Structure-Based Drug Design with a Deep Hierarchical Generative Model. [PDF]

J Chem Inf Model
Weller JA, Rohs R.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Toward the Bayesian brain: a generative model of information transmission by vestibular sensory neurons. [PDF]

Front Neurol
Paulin MG, Pullar KF, Hoffman LF.
europepmc   +1 more source

Enhanced cell tracking using a GAN-based super-resolution video-to-video time-lapse microscopy generative model. [PDF]

iScience
Zargari A, Mashhadi N, Shariati SA.
europepmc   +1 more source

SPLANG-a synthetic poisson-lognormal-based abundance and network generative model for microbial interaction inference algorithms. [PDF]

Sci Rep
Qian W, Stanley KG, Aziz Z, Aziz U, Siciliano SD.   +4 more
europepmc   +1 more source

AI nutrition recommendation using a deep generative model and ChatGPT. [PDF]

Sci Rep
Papastratis I, Konstantinidis D, Daras P, Dimitropoulos K.   +3 more
europepmc   +1 more source