Results 161 to 170 of about 24,500,069 (341)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Generative artificial intelligence (AI) applications in structural design face persistent challenges due to training data limitations, particularly datasets that lack compliance with critical physical and material requirements.
Guan, Hong +3 more
core +1 more source
Auxiliary Deep Generative Models [PDF]
, 2016 Deep generative models parameterized by neural networks have recently achieved state-of-the-art performance in unsupervised and semi-supervised learning.
Sønderby, Casper Kaae +3 more
core
Synthetic promoter design in Escherichia coli based on multinomial diffusion model
iScienceSummary: Generative design of promoters has enhanced the efficiency of de novo creation of functional sequences. Though several deep generative models have been employed in biological sequence generation, including variational autoencoder (VAE) or ...
Qixiu Du +8 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Theorizing and strategizing with models: Generative models of business models [PDF]
The ambiguity surrounding model-based science is exemplified by the proliferation of meanings of the term "business model". We argue that a clearer specification of the analytical, theoretical and ontological validity of models is an opportunity to learn
Seelos, Christian
core
GenPhys: From Physical Processes to Generative Models
, 2023 Since diffusion models (DM) and the more recent Poisson flow generative models (PFGM) are inspired by physical processes, it is reasonable to ask: Can physical processes offer additional new generative models? We show that the answer is yes. We introduce
Xu, Yilun +4 more
core
The role of generative AI in medical image synthesis: A review
Discover Applied SciencesMedical imaging is transformed with Generative artificial intelligence (AI) that offers robust tools for image synthesis, data augmentation and enhancement of image quality.
Ajay Karmakar +6 more
doaj +1 more source
Cross-domain convergence of generative models: From biomedical to astronomical applications
Machine Learning with ApplicationsThis paper investigates the convergence of generative modeling techniques across diverse image analysis tasks by examining their application in two data-intensive scientific domains: biomedical imaging and astronomy.
Hajer Ghodhbani +3 more
doaj +1 more source