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Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

open access: yesAdvanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu   +8 more
wiley   +1 more source

Selection for Function in Early Life: Implications for Early-Onset Pathologies. [PDF]

open access: yesEvol Appl
Asselin K   +10 more
europepmc   +1 more source

Family history of ADHD associates with stronger problem-solving skills amongst 2- to 3-year-olds. [PDF]

open access: yesJCPP Adv
Hendry A   +12 more
europepmc   +1 more source

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