Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Natal Bodies, Mortal Bodies, Sexual Bodies: Reading Gender, Desire, and Kinship through Reiner Schürmann’s Broken Hegemonies [PDF]
, 2012 Bianchi, Emanuela
core
Developing Micro/Nanostructured Fluidic Mixing Technology for Biomedical Applications
Advanced Science, EarlyView.This review critically evaluates how micro/nanostructured mixing technologies are redefining biomedical research. By synergizing fundamental analysis, numerical modeling, structural design, and external field manipulation, these systems attain unprecedented control over mass transport.
Junkai Wang +3 more
wiley +1 more source
Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning
Advanced Science, EarlyView.ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen +6 more
wiley +1 more source
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
Advanced Science, EarlyView.MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Predictors of Generativity Among SGM Midlife and Older Adults. [PDF]
GerontologistJung HH +3 more
europepmc +1 more source
Advanced Science, EarlyView.The human brain's imagination, which enables autonomous driving hazard avoidance by completing missing visual information, relies on Gaussian‐stochastic neuron. We report the altermagnetic RuO2 spintronic neurons integrating field‐free switching and intrinsic Gaussian stochasticity, building an all‐spin ANN for high‐quality image repairing and high ...
Junwei Zeng +9 more
wiley +1 more source
Augmented inventorship: rethinking patent law in the age of generative AI. [PDF]
J Law BiosciLevy HV.
europepmc +1 more source
Ion‐Gating Reservoir Computing for Preprocessing‐Free Speech Recognition from Throat Vibrations
Advanced Electronic Materials, EarlyView.This work presents a throat‐mounted mechanoelectric sensor integrated with an ion‐gel/graphene reservoir device for on‐device speech recognition. The system converts raw biomechanical vibrations into rich nonlinear current dynamics, enabling efficient classification through a simple linear readout. The approach highlights a compact and tunable physical‐
Daiki Nishioka +5 more
wiley +1 more source
Bridging Generations for Health and Social Cohesion: A Community-Based Intergenerational Model From Rural India. [PDF]
CureusJakasania AH, Misra S, Gupta SS.
europepmc +1 more source