Results 161 to 170 of about 425,706 (317)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Design study of a high temperature superconducting generator with YBCO windings
, 2010 This paper considers the merits of using a HTS rotor winding in a low-speed high-torque synchronous generator and the possibility of building a small-scale demonstrator to investigate the practicality of building such a machine.
Rotaru, Mihai D. +3 more
core
Известия высших учебных заведений. Поволжский регион:Технические наукиBackground. The purpose of this article is to study the effect of ultrasonic vibrations on the surface of a liquid for subsequent use in electric arc surfacing processes. Materials and methods.
A.A. Kazinskiy, D.V. Babakaev
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2008 The paper reports on an investigation to reduce harmonic content in the airgap flux density of a high temperature superconducting synchronous generator with a coreless rotor.
Lukasik, B. +4 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Design study of a high temperature superconducting generator with YBCO windings
, 2009 This paper considers the potential merits of using a HTS rotor winding in a low-speed high-torque synchronous generator and the possibility of building a small-scale demonstrator to investigate the practicality of building such a full-size machine ...
Lukasik, B. +3 more
core
Single-Pocket-Incision Generator Exchange From a Subcutaneous to an Extravascular Implantable Cardioverter-Defibrillator. [PDF]
J ArrhythmOnishi Y +4 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source