Results 101 to 110 of about 451,526 (293)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Counting minimal generator matrices [PDF]

, 1994
Given a particular convolutional code C, we wish to find all minimal generator matrices G(D) which represent that code. A standard form S(D) for a minimal matrix is defined, and then all standard forms for the code C are counted (this is equivalent to ...
Lumbard, Kim E., McEliece, Robert J.
core  

From Scattering Amplitudes to the Dilatation Generator in N=4 SYM

, 2012
The complete spin chain representation of the planar N=4 SYM dilatation generator has long been known at one loop, where it involves leading nearest-neighbor 2 -> 2 interactions.
Alday L F, Alday L F, Alday L F, Arkani-Hamed N, Arkani-Hamed N, Arkani-Hamed N, Arkani-Hamed N, Arutyunov G, Arutyunov G, Bargheer T, Bargheer T, Beisert N, Beisert N, Beisert N, Beisert N, Benjamin I Zwiebel, Berkovits N, Bombardelli D, Cachazo F, Drummond J, Drummond J M, Gromov N Kazakov V Leurent S Volin D, Gunaydin M, Ita H, Liendo P Pomoni E Rastelli L, Lipatov L N, Matsumoto T, Minahan J, Sever A Vieira P, Staudacher M, Zwiebel B I, Zwiebel B I   +31 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Precision matrix estimation using penalized Generalized Sylvester matrix equation

TEST, 2022
AbstractEstimating a precision matrix is an important problem in several research fields when dealing with large-scale data. Under high-dimensional settings, one of the most popular approaches is optimizing a Lasso or$$\ell _1$$ℓ1norm penalized objective loss function.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

QC-LDPC Codes Construction by Concatenating of Circulant Matrices as Block-Columns

International Journal of Information and Communication Technology Research, 2016
In this paper a new low complexity method for constructing binary quasi-cyclic low-density parity-check (QC-LDPC) codes is introduced. In the proposed method, each block-column of the parity check matrix H is made by a circulant matrix in a way that the ...
Mohammad Hesam Tadayon, Mohammad Mohammadi   +1 more
doaj  

Finding metastabilities in reversible Markov chains based on incomplete sampling

Special Matrices, 2017
In order to fully characterize the state-transition behaviour of finite Markov chains one needs to provide the corresponding transition matrix P. In many applications such as molecular simulation and drug design, the entries of the transition matrix P ...
Fackeldey Konstantin, Niknejad Amir, Weber Marcus   +2 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source