Results 211 to 220 of about 69,801 (268)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Scalable Boltzmann generators for equilibrium sampling of large-scale materials. [PDF]

Nat Commun
Schebek M, Noé F, Rogal J.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Cryptanalysis of some nonabelian group-based key exchange protocols. [PDF]

J Math Cryptol
Tinani S, Matteotti C, Rosenthal J.
europepmc   +1 more source

Editorial: The pharmacological effects and mechanisms of drugs against human diseases by modulating redox homeostasis, volume III. [PDF]

Front Pharmacol
Zhang X, Cui X, Xu M.
europepmc   +1 more source

Numerical backup protection scheme based on alienation indices of voltage and current measurements practically applied to synchronous generators. [PDF]

Sci Rep
Mahmoud RA, Salama MAE.
europepmc   +1 more source

Identification of peripheral pain generators with sigma-1 receptor Positron Emission Tomography/Magnetic Resonance Imaging in complex regional pain syndrome: initial study in a prospective trial. [PDF]

Pain
Baal JD, Ghimire P, Wagle S, Lewis M, Xu Y, Tawfik VL, Davidzon G, McCurdy CR, Biswal S, Yoon D.   +9 more
europepmc   +1 more source

3DOpt: Benchmark for Automated Design of 3D Molecular Structures across the Periodic Table. [PDF]

J Chem Inf Model
Costamagna M, Thomas M, Foscato M, Jensen VR.   +3 more
europepmc   +1 more source

Generation and/or generations?

, 2020
openaire   +1 more source