Results 181 to 190 of about 1,247,701 (302)

The impact of the consistency evaluation policy of generic drugs on the integration of innovation chain and industrial chain in the pharmaceutical manufacturing industry. [PDF]

Front Public Health
Xie Y, Zhang W.
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Criteria for unmet need in paediatric populations and their families: a literature-based case study in haematological malignancies in upper-middle and high-income countries. [PDF]

Front Pediatr
Van Isterdael C, Claessens Z, Huys I.
europepmc   +1 more source

Reconfigurable, Temperature Resilient Phase‐Change Metasurfaces Fabricated via High Throughput Nanoimprinting Lithography

Advanced Science, EarlyView.
ABSTRACT The combination of metasurfaces with chalcogenide phase‐change materials is a highly promising route toward the development of multifunctional and reconfigurable nanophotonic devices. However, their transition into real‐world devices is hindered by several technological challenges. This includes, amongst others, the lack of large area photonic
Carlota de Ruiz de Galarreta, Yinghao Zhao, Jose Mendoza‐Carreño, José M. Caicedo, José Santiso, C. David Wright, M. Isabel Alonso, Jiafang Li, Agustin Mihi   +8 more
wiley   +1 more source

The use of generic versus brand names in (clinical) pharmacology education across Europe: a cross-sectional survey. [PDF]

Eur J Clin Pharmacol
Slezáková V, Rychlíčková J, Cazaubon Y, Donker EM, van Leeuwen E, Likic R, Mazánková D, Piët JD, De Ponti F, Raasch W, van Rosse F, Sanz EJ, Schwaninger M, van Agtmael MA, Tichelaar J.   +14 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Identifying quality of life domains and facets affected in relapsing polychondritis: a qualitative analysis for the development of a disease-specific health-related quality of life instrument. [PDF]

Orphanet J Rare Dis
Mertz P, Sander O, Faria R, Crisafulli F, Silva-Ribeiro S, Kawka L, Sztejkowski C, Düsing C, Rose T, Lamas A, Vasconcelos C, Fontana G, Semeraro P, Neagu T, Resteu M, Damian L, Pamfil C, Bucsa C, Matthews LJ, Devilliers H, Rednic S, Arnaud L.   +21 more
europepmc   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

FAIR foundations of a novel indicator vault for non-communicable diseases in the European Union: feasibility study for effective contextualisation of indicators. [PDF]

Front Digit Health
Štotl I, Carinci F, Fava S, Lavens A, Lepiksone J, Massi Benedetti M, Poljičanin T, Cunningham S, Sándor J, Nicholson N.   +9 more
europepmc   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source