Results 251 to 260 of about 480,989 (325)

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Pakistan's first medicine price deregulation policy: assessing its impact on prices, affordability, and availability of oral anti-diabetic medicines in private pharmacies. [PDF]

Front Pharmacol
Saeed A, Shukar S, Yasin NA, Yang C, Jiang M, Aziz MM, Zahoor H, Sunnan-Ud-Din M, Fang Y, Babar ZU.   +9 more
europepmc   +1 more source

A Novel Metal Foam‐Supported Solid Oxide Fuel Cell With High Specific Power

Advanced Science, EarlyView.
Solid oxide fuel cells (SOFCs) employing metal foam supports with an ultrahigh porosity of 90% and average pore size of 100 µm are successfully fabricated. The metal foam architecture significantly enhances gas diffusion coefficients, effectively reducing concentration polarization while simultaneously decreasing areal mass.
Jingbo Ma, Ying Yang, Meng Ni, Yanxiang Zhang, Mufu Yan   +4 more
wiley   +1 more source

Facilitators and barriers to generic and biosimilar medications in the Middle East and North Africa: insights from physicians and pharmacists-a systematic review. [PDF]

Eur J Clin Pharmacol
Alqawasmeh KA, Mason T, Morris A, Hafez W, Hasan T, Taher S, Al Dweik R.   +6 more
europepmc   +1 more source

Enhancing Binding by Electron Transfer at Heterointerfaces of Biochar‐Modified Hydrogel to Improve Utilization Efficiency of Wastewater Recovered Nutrients

Advanced Science, EarlyView.
Enhancing the utilization efficiency of nutrients recovered from wastewater is achieved through hydrogel modification by biochar. The strategy improves nutrient binding to hydrogels via electron transfer at heterointerfaces, thereby reducing nutrient release rate.
Hao Hu, Juncong Zou, Chenglin Zhang, Peng Li, Junnan Li, Yen Wah Tong, Jun Li, Yiliang He   +7 more
wiley   +1 more source

A mixed-methods study investigating the potential and challenges of generic substitution of controlled substances in community pharmacies. [PDF]

Explor Res Clin Soc Pharm
Keller IM, Alexa JM, Meier MW, Allemann SS.   +3 more
europepmc   +1 more source

Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin‐induced Intestinal Injury by Production of Carboxylesterase EstB

Advanced Science, EarlyView.
Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao, Qing Li, Xiaowu Bai, Ertao Zhai, Weigang Dai, Yan Qian, Tianhao Zhang, Zhixin Huang, Ziyu Huang, Fangang Meng, Jianhui Chen, Tao Zuo, Shirong Cai, Risheng Zhao   +13 more
wiley   +1 more source

Longitudinal analysis of usage and public awareness of tyrosine kinase inhibitors for CML. [PDF]

Front Oncol
Schroer AE, Javadi T, Mehta A, Torlak F, McFarland JR, Kumar G, da Silva AL, Benjamin J, Choudhary MM, Sadeghi A, le Coutre P, Blaha MJ, Berning P, Dzaye O.   +13 more
europepmc   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

Effects of Generic Entry on Market Shares and Prices of Originator Drugs: Evidence from Chinese Pharmaceutical Market. [PDF]

Pharmacoecon Open
Li W, Li X, He Y, Shi L, Chen J.
europepmc   +1 more source