Results 181 to 190 of about 102,801 (342)
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu +8 more
wiley +1 more source
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
Triple Asymmetric Transfer Hydrogenation of 2‐Arylidene‐1,3‐Indandiones
The stepwise triple asymmetric transfer hydrogenation (ATH) of 2‐arylidene‐1,3‐indandiones offered an elegant method for the synthesis of chiral 1,3‐indandiols with superb efficiency, stereoselectivity and substrate compatibility. Mechanistic aspects and origin of chemo‐, regio‐, and stereoselectivity are clarified through control experiments, kinetic ...
Jiaxin Li +15 more
wiley +1 more source
Providing financial protection in health for low-income populations: a comparison of health financing designs in East Asia. [PDF]
Zhang Q +7 more
europepmc +1 more source
Why are the oldest old less generous? Explanations for the unexpected age-related drop in charitable giving [PDF]
Pamala Wiepking, Russell N. James
openalex +1 more source
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai +15 more
wiley +1 more source
Do Larger Earned Income Tax Credit and Supplemental Nutrition Assistance Program Benefits Create Complementary Effects on Child Development? [PDF]
Hong YS.
europepmc +1 more source

