Results 191 to 200 of about 391,792 (372)

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Zoborg: On‐Demand Climbing Control for Cyborg Beetles

Advanced Science, EarlyView.
A novel on‐demand climbing protocol enables Zoborg (a cyborg beetle from the living Zophobas morio) to seamlessly transition from horizontal floors to vertical walls. Multiple unrestrained mechanosensors allow wall sensing while electrical stimulation of the elytron initiates climbing. Leveraging the agile locomotion and exceptional adaptability of the
Lachlan Fitzgerald, H. Nhan Le, Robbie S. Wilson, H. Duoc Nguyen, Thanh Nho Do, T. Thang Vo‐Doan   +5 more
wiley   +1 more source

Extensive or Intensive Generosity? The Price and Income Effects of Federal Grants [PDF]

, 2005
Katherine Baicker
openalex   +1 more source

Demographics and Volatile Social Security Wealth: Political Risks of Benefit Rule Changes in Germany [PDF]

In this paper we address the question how the generosity of the benefit rule of the German public pension system has changed during the past three decades and how this development can be explained by demographic changes.
Christoph Borgmann, Matthias Heidler
core  

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

Advanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
wiley   +1 more source

Measuring the Changing Generosity of Unemployment Benefits: Beyond Existing Indicators [PDF]

, 2005
Gayle Allard
openalex   +1 more source

Overwhelming generosity [PDF]

British Dental Journal, 2013
openaire   +2 more sources

Generosity in the midst of adversity [PDF]

Intensive Care Medicine, 2021
openaire   +3 more sources

Perovskite‐Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for Ultrasensitive Cytokine Detection

Advanced Science, EarlyView.
This work proposes the first perovskite/graphene heterostructure‐based FET biosensor with uniquely biotunable ternary logic gating functionality for the detection of human IL6 cytokines. The biosensor integrates a lateral perovskite‐on‐graphene heterostructure phototransistor with a vertical bio‐nano‐photonic filter, achieving ultrahigh sensitivity ...
Jiaxing Sun, Lin Zhou, Zening Li, Guolin He, Hongju Mao, Jianlong Zhao, John A. Hunt, Xianfeng Chen   +7 more
wiley   +1 more source

First Synthesis of Optically Pure Propargylic N-Hydroxylamines by Direct, Highly Diastereoselective Addition of Terminal Alkynes to Nitrones We thank the ETH, Roche Research Foundation, the Swiss National Science Foundation, Merck, and Aventis for their generous support.

, 2002
Roger Fässler, Doug E. Frantz, J. Oetiker, Erick M. Carreira   +3 more
openalex   +1 more source