Results 51 to 60 of about 391,792 (372)
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Cross-cultural study of kinship premium and social discounting of generosity
Frontiers in Psychology, 2023 Social discounting predicts that one’s concern for others decreases with increasing social distance. Cultural dimensions may influence this social behavior.
Jiawei Liu +19 more
doaj +1 more source
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source
Teacher’s Generosity as the Counteraction to the Young People’s Hardening Pedagogic
Образование и наука, 2015 The paper analyzes the growing tendency for young people’s harden- ing. According to the authors that phenomenon is caused by such current trends as the language degradation, the militaristic and alienation vocabulary predominance re- sulting in ...
O. B. Akimova, A. S. Frants
doaj +1 more source
Be optimistic or be cautious? Affective forecasting bias in allocation decisions and its effect
Frontiers in Psychology, 2022 IntroductionPeople’s forecasts of their future emotions play an essential role in their behavior and experience of well-being. However, their emotional reactions may fall short of what they expect, which has implications for subsequent decision making ...
Lei Liu +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti +5 more
wiley +1 more source
Opera slavica, 2016 This article deals with determining metaphoric models (concept metaphors) as relevant cognitive features of the concept GENEROSITY in British, German, Ukrainian and Russian language societies on the basis of their phraseological objectivation.
Oleksandr Oleksandrovyč Petrov
doaj
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
A formação de personalidades éticas: representações de si e moral
Psicologia: Teoria e PesquisaO artigo apresenta os estudos de uma investigação atual entre 75 adolescentes de 12 a 15 anos, estudantes de colégios particulares da cidade de Campinas, que tem como principal objetivo constatar a possível correspondência entre os julgamentos morais e ...
Luciene Regina Paulino Tognetta +1 more
doaj +1 more source