Results 271 to 280 of about 900,077 (291)
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Gene-Based Therapies for Dominant Retinopathies
Current Gene Therapy, 2010Over the past two decades, significant progress has been made in defining the molecular pathogenesis of hereditary retinal degenerations. Many of these are characterised by immense genetic heterogeneity. For example, in retinitis pigmentosa (RP), the most common form of this group of disorders, approximately 50 disease causing genes have been ...
G. Jane Farrar +3 more
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The evolution of plasmodial stage-specific rRNA genes is dominated by gene conversion
Journal of Molecular Evolution, 1991Plasmodium species exhibit the unprecedented situation of distinct, stage-specific rRNA sequences. We present an analysis of two pairs of sequences of the small rRNA subunit (Plasmodium falciparum and Plasmodium berghei) and show that these genes do not evolve independently and that in fact their evolution is dominated by gene conversion. This analysis
V, Enea, V, Corredor
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Functional inactivation of genes by dominant negative mutations
Nature, 1987Molecular biologists are increasingly faced with the problem of assigning a function to genes that have been cloned. A new approach to this problem involves the manipulation of the cloned gene to create what are known as 'dominant negative' mutations.
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A dominant gene for yellow fruit in the raspberry
Euphytica, 1975A gene for yellow fruit, designated Y, segregated in progenies obtained by crossing R. phoenicolasius with the red raspberry and backcrossing to the raspberry. Another gene, designated Ys, suppressed its expression in R. phoenicolasius itself and in the F1.
D. L. Jennings, Eleanor Carmichael
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Gene dosage balance: deletions, duplications and dominance
Trends in Genetics, 2005The number of known human genes whose heterozygous null alleles lead to disease (i.e. haploinsufficient genes) is increasing. A recent update shows that they encode preferentially structural proteins, transcription regulators, signal transduction elements and various binding factors [1].
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Gene expression and parental dominance in hybrid plants
Development, 1990ABSTRACT Genomic imprinting, where the genes from one parent have different expression properties to those of the other parent, occurs in plants. It has potentially significant consequences because of the importance of hybrids in plant evolution and plant breeding, and provides a mechanism that can hide genetic variation for many ...
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Dominant maternal interactions with Drosophila segmentation genes
Roux's Archives of Developmental Biology, 1988A systematic search for X chromosome loci showing a dominant maternal interaction with the segmentation genes Krüppel, hunchback, knirps and hairy was performed using deficiencies spanning 65% of the X chromosome. No interaction with the knirps gene was observed, but five regions of the X chromosome showed a maternal dominant interaction with the ...
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Maximum Rate of Selection for Dominant Quantitative Genes
Nature, 1946THE following formulae are proposed to measure the maximum rate of progress of selection for dominant quantitative genes. To simplify the problem, certain assumptions are made: (1) Selection begins in the F2 generation of a cross between two pure lines. (2) All genes are dominant in the positive direction.
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LRRK2 Gene and Tremor-Dominant Parkinsonism
Archives of Neurology, 2006Kristoffer, Haugarvoll +3 more
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