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Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development. [PDF]

open access: yesJ Clin Invest
Wu H   +18 more
europepmc   +1 more source
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Reporter Gene Imaging

American Journal of Roentgenology, 2013
The purposes of this article are to summarize the basic concept and the strategies of reporter imaging; introduce reporter genes frequently used in optical imaging, nuclear medicine, and MRI for in vivo application; and show typical examples of reporter gene imaging.In molecular biology, many reporter genes have been developed for monitoring cellular ...
Hyewon, Youn, June-Key, Chung
openaire   +2 more sources

Reporter gene expression for monitoring gene transfer

Current Opinion in Biotechnology, 1997
The use of reporters such as green fluorescent protein (GFP) and firefly luciferase permit highly sensitive and nondestructive monitoring of gene transfer and expression. Modifications in GFP which increase intensity and thermostability, as well as alter its spectral qualities, have facilitated the use of GFP in a variety of gene transfer methods ...
S, Welsh, S A, Kay
openaire   +2 more sources

Monitoring gene therapy with reporter gene imaging

Seminars in Nuclear Medicine, 2001
Rapid advances in imaging technologies and gene transfer strategies offer a great opportunity to optimize clinical trials of human gene therapy. Reporter genes are emerging as very powerful tools to monitor the delivery, magnitude, and time variation of therapeutic gene transfer in vivo.
P, Ray   +7 more
openaire   +2 more sources

CEST MRI Reporter Genes

2010
In recent years, several reporter genes have been developed that can serve as a beacon for non-invasive magnetic resonance imaging (MRI). Here, we provide a brief summary of recent advances in MRI reporter gene technology, as well as detailed "hands-on" protocols for cloning, expression, and imaging of reporter genes based on chemical exchange ...
Guanshu, Liu   +2 more
openaire   +2 more sources

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