Results 91 to 100 of about 11,860,410 (381)
Translational Neurodegeneration, 2021 Background β Amyloid (Aβ)-mediated neuronal hyperactivity, a key feature of the early stage of Alzheimer’s disease (AD), is recently proposed to be initiated by the suppression of glutamate reuptake.
Yifei Bao +5 more
doaj +1 more source
Cavity-assisted squeezing of a mechanical oscillator
, 2009 We investigate the creation of squeezed states of a vibrating membrane or a movable mirror in an opto-mechanical system. An optical cavity is driven by squeezed light and couples via radiation pressure to the membrane/mirror, effectively providing a ...
Genes, C. +5 more
core +1 more source
Oncometabolites: tailoring our genes [PDF]
, 2015 Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Gene–Gene and Gene–Environment Interactions in Apolipoprotein L1 Gene-Associated Nephropathy [PDF]
Clinical Journal of the American Society of Nephrology, 2014 Molecular genetics have revolutionized the understanding of susceptibility to the broad spectrum of kidney diseases with light microscopic appearance of FSGS, particularly in populations with recent African ancestry. These disorders include idiopathic FSGS, HIV-associated nephropathy, severe lupus nephritis, sickle cell nephropathy, and the primary ...
Barry I. Freedman, Karl Skorecki
openaire +3 more sources
Emergence of atom-light-mirror entanglement inside an optical cavity
, 2008 We propose a scheme for the realization of a hybrid, strongly quantum-correlated system formed of an atomic ensemble surrounded by a high-finesse optical cavity with a vibrating mirror.
C. Genes +4 more
core +1 more source
Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes [PDF]
, 2010 Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells ...
Dandekar, D. +5 more
core +2 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
BMC Genomics, 2017 Background Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae.
Jing Zuo +9 more
doaj +1 more source
Differential usage of DNA modifications in neurons, astrocytes, and microglia
Epigenetics & Chromatin, 2023 Background Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neuroscience, there is a pressing need to isolate and characterize the epigenomes of specific CNS cell types in health and ...
Kyla B. Tooley +8 more
doaj +1 more source