Results 91 to 100 of about 4,979,257 (318)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

What's in our genes?

, 2003
review of Nature Via Nurture: Genes, Experience and What Makes Us Human, by Matt ...
Shakespeare, Tom
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The gene: An appraisal

Progress in Biophysics and Molecular Biology, 2021
The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis.
openaire   +2 more sources

High-throughput trapping of secretory pathway genes in mouse embryonic stem cells [PDF]

, 2006
High-throughput gene trapping is a random approach for inducing insertional mutations across the mouse genome. This approach uses gene trap vectors that simultaneously inactivate and report the expression of the trapped gene at the insertion site, and ...
Hansen, J., von Melchner, H., Wurst, W., Schnütgen, Frank, Seisenberger, C., Floss, Thomas, Seisenberger, Claudia, Hansen, Jens, Ruiz, Patricia, Ruiz, P., Schnütgen, F., Hollatz, M., De-Zolt, Silke, De-Zolt, S., Floss, T., Hollatz, Melanie, Wurst, Wolfgang, Melchner, Harald von (Prof. Dr.), De-Zolt, S.;Schnütgen, F.;Seisenberger, C.;Hansen, J.;Hollatz, M.;Floss, T.;Ruiz, P.;Wurst, W.;von Melchner, H., S. De-Zolt   +19 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Reconstrução do sulco interglúteo: relato de caso Intergluteal sulcus reconstruction: case report

Revista Brasileira de Cirurgia Plástica, 2011
INTRODUÇÃO: O conceito de beleza feminina tem mudado ao longo dos anos, porém a forma e a projeção das nádegas permanecem como símbolos de máxima feminilidade.
Genes Lopes de Almeida Junior
doaj   +1 more source

Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes [PDF]

, 2010
Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells ...
Hu, Z.Y., Hu, Z., Verhoeven, G., De Gendt, K., Dandekar, D., Wilkinson, M.F., Wilkinson, M., O'Shaughnessy, P.J.   +7 more
core   +1 more source

Illegitimate Recombination between Duplicated Genes Generated from Recursive Polyploidizations Accelerated the Divergence of the Genus Arachis

, 2021
The peanut (Arachis hypogaea L.) is the leading oil and food crop among the legume family. Extensive duplicate gene pairs generated from recursive polyploidizations with high sequence similarity could result from gene conversion, caused by illegitimate ...
Feng, Yishan, Wang, Li, Ge, Weina, Sangrong Sun, Wang, Zhenyi, Li, Yuxian, Tianyu Lei, Wei, Chendan, Sun, Sangrong, Teng, Jia, Jianyu Wang, Yuan, Min, Zhang, Yan, Min Yuan, Jiaqi Wang, Jinpeng Wang, Shaoqi Shen, Yanan Hao, Zhang, Lan, Qimeng Xiao, Yishan Feng, Shen, Shaoqi, Wang, Jianyu, Wang, Jinpeng, Xiao, Qimeng, Hao, Yanan, Weina Ge, Shoutong Bao, Zhenyi Wang, Li Wang, Yuxian Li, Lan Zhang, Yan Zhang, Chendan Wei, Bao, Shoutong, Wang, Jiaqi, Jia Teng, Le, Tianyu   +37 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source