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Tandem genes and clustered genes
Journal of Theoretical Biology, 1995Two patterns of gene repetition are described: tandem arraying and clustering. Tandemly arrayed genes reside within segments of DNA that are repeated head-to-tail a number of times. Clustered genes are linked but irregularly spaced, are often mutually inverted in an unpredictable pattern and are connected by non-conserved DNA.
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Gene function, gene networks and the fate of duplicated genes
Seminars in Cell & Developmental Biology, 1999For both copies of a duplicated gene to become fixed in a population and subsequently maintained, selection must favour individuals with both genes over individuals with one. Here I review and assess some of the proposed ways that gene structure and function might affect the likelihood of both copies acquiring distinct functions and therefore positive ...
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Gene-Gene Interaction and Epistasis
2011This chapter defines the differing meanings of the words gene-gene interaction and “epistasis”. Epistasis can be loosely defined as the interaction between two or more genes. The differences between biological and statistical epistasis are examined and the decomposition of genetic variance in any system into single-locus and epistatic components of ...
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Gene Duplication and Gene Loading
2014During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
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Gene-gene and gene-environment interactions in lipodystrophy
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2019Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically ...
Broekema, M. F. +3 more
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A Gene-Based Approach for Testing Gene × Gene and Gene × Environment Interactions
2016The importance of the gene × gene (G × G) and gene × environment (G × E) interaction has been widely recognized. It is statistically challenging to account for interactions in the analysis of genome-wide association data. In this chapter, we introduce a gene-based method for modeling G × G and G × E interactions under the regression framework.
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The phenotypic landscape of essential human genes
Cell, 2022Luke Funk, Jimmy Ly, Paul C Blainey
exaly