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Royal Institute of Philosophy Supplement, 2005
Contrary to one possible interpretation of my title, this paper will not advocate any scepticism or ontological deflation. My concern will rather be with how we should best think about a realm of phenomena the existence of which is in no doubt, what has traditionally been referred to as the genetic.
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Contrary to one possible interpretation of my title, this paper will not advocate any scepticism or ontological deflation. My concern will rather be with how we should best think about a realm of phenomena the existence of which is in no doubt, what has traditionally been referred to as the genetic.
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Gene-for-Gene Interactions [PDF]
Traditionally, measures to prevent viral diseases have included breeding strategies to introduce natural forms of plant resistance from wild relatives into economically important crops. Thus, many crop plants have been selectively bred to incorporate specific resistance genes that target a wide variety of pathogens (Fraser, 1990).
James N. Culver, Christopher D. Dardick
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Gene-Gene and Gene-Environment Interactions
2018Identifying gene-gene and gene-environment interactions may help us to better describe the genetic architecture for complex traits. While advances have been made in identifying genetic variants associated with complex traits through more dense panels of genetic variants and larger sample sizes, genome-wide interaction analyses are still limited in ...
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Analysis of Gene‐Gene Interactions
Current Protocols in Human Genetics, 2003AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
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1967
Mendel was ahead of his time, but he was not so far ahead that he could not arrive at the first great generalizations of genetics—his first and second laws. How fortunate that Mendel did not discover linkage, for he might then have failed to deduce the second law.
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Mendel was ahead of his time, but he was not so far ahead that he could not arrive at the first great generalizations of genetics—his first and second laws. How fortunate that Mendel did not discover linkage, for he might then have failed to deduce the second law.
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2012
Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Xiaofeng Zhu+3 more
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Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Xiaofeng Zhu+3 more
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Inference: International Review of Science, 2018
A new study, “Russian Doll Genes and Complex Chromosome Rearrangements in Oxytricha trifallax,” casts fresh light on gene nesting and mathematical patterns. Tyler Hampton examines the key findings.
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A new study, “Russian Doll Genes and Complex Chromosome Rearrangements in Oxytricha trifallax,” casts fresh light on gene nesting and mathematical patterns. Tyler Hampton examines the key findings.
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Better Gene Expression by (-)Gene than by (+)Gene in Phage Gene Delivery Systems
Biotechnology Progress, 2006In recent years, capsid-modified filamentous bacteriophage has become a potential vector for gene delivery into mammalian cells. However, little was known about how the carried gene in the single-stranded genome expressed in mammalian cells. To explore whether the orientation of the carried gene affects its expression in the cells, we prepared EGF ...
Jianren Gu+9 more
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Tandem genes and clustered genes
Journal of Theoretical Biology, 1995Two patterns of gene repetition are described: tandem arraying and clustering. Tandemly arrayed genes reside within segments of DNA that are repeated head-to-tail a number of times. Clustered genes are linked but irregularly spaced, are often mutually inverted in an unpredictable pattern and are connected by non-conserved DNA.
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Gene Duplication and Gene Loading
2014During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
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