Results 191 to 200 of about 9,996,988 (405)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Genetics: The genetic watchmaker [PDF]

Nature, 2013
openaire   +2 more sources

AN EXPERIMENTAL STUDY OF INTERACTION BETWEEN GENETIC DRIFT AND NATURAL SELECTION [PDF]

, 1957
Theodosius Dobzhansky, Olga Pavlovsky
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

How epigenetic evolution can guide genetic evolution (abstract)

, 2008
The expression level of a gene in future generations can be modified both by genetic mutations and by the attachment of methyl groups to the DNA. Since the DNA methylation pattern along a genome is inherited, methylation patterns constitute a significant
Groom, Graeme, Mills, Rob, Watson, Richard A.   +2 more
core  

The Cytological Basis of Genetical Interference

, 1931
J. B. S. Haldane
openalex   +2 more sources

Genetical behavior of heteromorphic homologous chromosomes of circotettix (Orthoptera) [PDF]

, 1921
E. Eleanor Carothers
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

SUPPRESSIVENESS: A NEW FACTOR IN THE GENETIC DETERMINISM OF THE SYNTHESIS OF RESPIRATORY ENZYMES IN YEAST

, 1955
Boris Ephrussi, Hélène de Margerie-Hottinguer, Herschel Roman   +2 more
openalex   +1 more source

Genetic Control of Sodium and Potassium Concentrations in the Red Blood Cells of Sheep [PDF]

, 1955
J. V. Evans, J. W. B. King
openalex   +1 more source