Results 191 to 200 of about 7,786,025 (339)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Delphi panel consensus on genetic testing for prostate cancer in Australia: Whom to test and how? [PDF]

Fam Cancer
Edmunds K, Arora S, Teppala S, Scuffham P, Fairbairn D, Roberts MJ, Horvath L, Smith DP, Tuffaha H.   +8 more
europepmc   +1 more source

THE GENETIC BASIS OF HYPER-SYNTHESIS OF ß-GALACTOSIDASE [PDF]

, 1963
Tadao Horiuchi, Sumiko Horiuchi, Aaron Novick   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Extending the Use of Mendelian Randomisation With Non-Inherited Variants to Assess Socially Transmitted Parental Exposures Under Assortative Mating. [PDF]

Genet Epidemiol
Woolf B, Mason A, Shapland CY, Kang H, Sallis HM, Burgess S, Munafò MR.   +6 more
europepmc   +1 more source

GENE CONVERSION AND TRANSFER OF GENETIC INFORMATION WITHIN THE INVERTED REGION OF INVERSION HETEROZYGOTES [PDF]

, 1973
Arthur Chovnick
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Climatic Variables and Virulence May Contribute to the Population Dynamics of Pyricularia oryzae at Local Scale. [PDF]

Microbiologyopen
Bosco S, Sillo F, Ruffa P, Bergonzi L, Tenni D, Abbruscato P, Torello Marinoni D, Romani M, Spadaro D.   +8 more
europepmc   +1 more source

Immunohistochemical and molecular genetic profiling of acquired cystic disease‐associated renal cell carcinoma [PDF]

, 2009
Chin‐Chen Pan, Yann‐Jang Chen, Liang‐Che Chang, Yen‐Hwa Chang, D M‐T Ho   +4 more
openalex   +1 more source