Results 201 to 210 of about 9,996,988 (405)

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

Journal of Computational Chemistry, 1998
G. Morris, D. Goodsell, R. S. Halliday, R. Huey, W. Hart, R. Belew, A. Olson   +6 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

OBSERVATIONS ON DOUBLE ALBUMIN: A GENETICALLY TRANSMITTED SERUM PROTEIN ANOMALY *† [PDF]

, 1959
David P. Earle, M. Hütt, Karl Schmid, David Gitlin   +3 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The transmission ability in a population of elite tetraploid potatoes. [PDF]

Plant Genome
Aalborg T, Romé H, Ranzau C, Bagge M, Jensen J, Nielsen KL.   +5 more
europepmc   +1 more source

Genetic Linkage in the Rabbit

, 1941
W. E. Castle, P. B. Sawin
openalex   +1 more source

A Systematic Study of the North American Melanthaceae from the Genetic Standpoint. [PDF]

, 1918
R. Ruggles Gates
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution. [PDF]

Evol Anthropol
Kasser SM, Lala KN, Fortunato L, Feldman MW.   +3 more
europepmc   +1 more source

GENETIC FACTORS AFFECTING MATING TYPE FREQUENCIES IN VARIETY 1 OF TETRAHYMENA PYRIFORMIS [PDF]

, 1959
David L. Nanney
openalex   +1 more source