Results 241 to 250 of about 7,018,639 (311)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Large future genetic diversity losses are predicted from conservation indicators even with habitat protection. [PDF]

Proc Natl Acad Sci U S A
Mualim KS, Spence JP, Weiß C, Selmoni O, Lin M, Exposito-Alonso M.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Confluent and Reticulated Papillamotosis-A Case Report

Haseki Tıp Bülteni, 2010
Yavuz Yeflilova, fiule Bak›r
doaj  

Genetic evaluation of early-onset atrial fibrillation: impact on patient management. [PDF]

Eur Heart J
Laws JL, Shabani M, Williams HL, Grauherr DD, Kilbourne WM, Crawford DM, Ogunmola I, Sun L, Virk Z, Cathey B, El-Harasis MA, Pelphrey CJ, Quintana JA, Murphy BS, Davogustto GE, Ponder ME, Irani OM, Daw JM, Varghese BT, Saavedra P, Abraham RL, Estrada JC, Murray KT, Clair WK, Shen ST, Kanagasundram AN, Montgomery JA, Ellis CR, Fish F, Richardson TD, Crossley GH, Hung RR, Dendy JM, Wright A, Wells QS, Ye F, Tandri H, Stevenson WG, Lancaster M, Kannankeril PJ, Stevenson LW, Roden DM, Yoneda ZT, Shoemaker MB.   +43 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap. [PDF]

EBioMedicine
Stinson SE, Shadrin AA, Rahman Z, Rødevand L, Broce IJ, Selbæk G, Stefansson H, Haavik J, Parker N, Koch E, Frei O, O'Connell KS, Smeland OB, Djurovic S, Dale AM, van der Meer D, Andreassen OA.   +16 more
europepmc   +1 more source

A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating. [PDF]

Genetics
Krätschmer I, Robinson MR.
europepmc   +1 more source

Re-Interpreting Genetic Offset: Quantifying the Least Required Evolutionary Rate Under Climate Change at the Mediterranean Range Margin of European Beech. [PDF]

Evol Appl
Morando-Milà J, Grau O, Ulaszewski B, Vilà-Cabrera A, Peñuelas J, Jump A, Scotti I.   +6 more
europepmc   +1 more source

Complementary Evidence From Historical and Contemporary Gene Dispersal Reveals Contrasting Population Dynamics in a Tropical Tree Species. [PDF]

Evol Appl
Bonnier J, Heuertz M, Traissac S, Brunaux O, Lepais O, Troispoux V, Chancerel E, Compagnie Z, Tysklind N.   +8 more
europepmc   +1 more source