Results 51 to 60 of about 6,238,924 (364)

Genetic diversity analysis and DNA fingerprinting of tomato breeding lines using ssr markers

open access: yesAgraarteadus, 2021
There is a need to expand the information on genetic relationships between tomato (Solanum lycopersicum L.) lines to improve hybridization breeding. The genetic diversity and relationships among 24 tomato lines were evaluated by simple sequence repeat ...
Aziz Mahdi Abd Al-Shammari   +1 more
doaj   +1 more source

An integrated map of genetic variation from 1,092 human genomes

open access: yesNature, 2012
By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease.
Gil A. David M. Richard M. Gonçalo R. David R. Aravind McVean Altshuler (Co-Chair) Durbin (Co-Chair) Abec   +499 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

The impact of pRAP vectors on plant genetic transformation and pathogenesis studies including an analysis of BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1)-mediated resistance

open access: yesJournal of Plant Interactions, 2021
Crop improvement can be facilitated through efficient gene transfer, leading to pRAP plasmid development. Comparative hairy root transformation results from 24 previously published articles examining 29,756 roots show a 70% transformation efficiency ...
Vincent P. Klink   +3 more
doaj   +1 more source

Resizing the productive characteristics of meat-type quail through principal component analysis [PDF]

open access: yesArquivo Brasileiro de Medicina Veterinária e Zootecnia, 2020
This study aimed to establish criteria for eliminating redundant variables, to know the magnitude of the data relationship, and to provide information that helps researchers in the use of the technique to analyze and interpret production data and egg ...
D.U. Tyska   +6 more
doaj   +2 more sources

Functional mapping and annotation of genetic associations with FUMA

open access: yesNature Communications, 2017
A main challenge in genome-wide association studies (GWAS) is to pinpoint possible causal variants. Results from GWAS typically do not directly translate into causal variants because the majority of hits are in non-coding or intergenic regions, and the ...
Kyoko Watanabe   +3 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Genetics and sports [PDF]

open access: yesBritish Medical Bulletin, 2009
The limit of each individual to perform a given type of exercise depends on the nature of the task, and is influenced by a variety of factors, including psychology, environment and genetic make up. Genetics provide useful insights, as sport performances can be ultimately defined as a polygenic trait.We searched PubMed using the terms 'sports' and ...
Lippi G, Longo UG, MAFFULLI, Nicola
openaire   +6 more sources

Mathematical model for studying genetic variation in terms of restriction endonucleases.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1979
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species.
M. Nei, W. -. Li
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

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