Results 181 to 190 of about 206,658 (295)

Advancing access to genome sequencing for rare genetic disorders: recent progress and call to action [PDF]

Vaidehi Jobanputra, Brock E. Schroeder, Heidi L. Rehm, Wei Shen, Elizabeth Spiteri, Ghunwa Nakouzi, Stacie L. Taylor, Christian R. Marshall, Linyan Meng, Stephen F. Kingsmore, Katarzyna A. Ellsworth, Euan A. Ashley, Ryan J. Taft   +12 more
openalex   +1 more source

Studies on Genetic Variability, Heritability and Genetic Advance for Yield and Yield Components in Drought Tolerant Rice (Oryza sativa L.) Landraces [PDF]

, 2018
S. K. Singh, Monika Singh, Prudhvi Raj Vennela, D. K. Singh, Shubhra Natasha Kujur, Dinesh Kumar   +5 more
openalex   +1 more source

An advance about the genetic causes of epilepsy

, 2021
Yu Sun, Licheng Lu, Lanxin Li, Jingbo Wang   +3 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Progress in Wildlife Conservation, Management and Biological Research: From Molecular Perspectives to Ecological Processes. [PDF]

Biology (Basel)
Srbek-Araujo AC.
europepmc   +1 more source

The Study of Genetic Diversity, Heritability and Genetic Advance of Morphological Traits, Yield and Yield Components in Different Chickpea (Cicer arietinum) Genotypes [PDF]

, 2018
Payam Pezeshkpour, Soheila Afkar
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Advancing genome-based precision medicine: a review on machine learning applications for rare genetic disorders

Shabbar Abbas, Zeeshan Abbas, Arifa Zahir, Seung Won Lee   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Genetic Evaluation for Variability, Heritability and Genetic Advance in Cucumber (Cucumis sativus L.) Genotypes

Himani Shukla, D. K. Upadhyay, Aastik Jha, Sunil Kumar Paswan, Awaneesh Pratap Singh, R. L. Yadav   +5 more
openalex   +1 more source