Results 151 to 160 of about 8,395,489 (400)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Size Optimization of Space Structures Using Genetic Algorithm and Gradient Methods [PDF]

open access: yesفصلنامه علوم و فناوری فضایی, 2010
Weight optimization is one of important parameters in space structure design. Size optimization is usually performed using gradient or genetic algorithm. Gradient algorithm is based on derivation of objective function and constraints of problem.
A. Vafaeesefat, S. H. Tabatabai
doaj  

Genetic Optimization of Keywords Subset in the Classification Analysis of Texts Authorship [PDF]

open access: yesarXiv, 2012
The genetic selection of keywords set, the text frequencies of which are considered as attributes in text classification analysis, has been analyzed. The genetic optimization was performed on a set of words, which is the fraction of the frequency dictionary with given frequency limits.
arxiv  

Hybrid Genetic Algorithms

open access: yes, 2022
Hybrid optimization methods have known significant interest in recent years and are being growingly used to solve complex problems in science and engineering. For instance, the famous evolutionary Genetic Algorithm can integrate other techniques within its framework to produce a hybrid global algorithm that takes advantages of that combination and ...
openaire   +2 more sources

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

open access: yesMolecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien   +7 more
wiley   +1 more source

Boundary Evolution Algorithm for SAT-NP [PDF]

open access: yesarXiv, 2018
A boundary evolution Algorithm (BEA) is proposed by simultaneously taking into account the bottom and the high-level crossover and mutation, ie., the boundary of the hierarchical genetic algorithm. Operators and optimal individuals based on optional annealing are designed.
arxiv  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

open access: yesMolecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song   +13 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy