Results 151 to 160 of about 8,395,489 (400)
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Size Optimization of Space Structures Using Genetic Algorithm and Gradient Methods [PDF]
فصلنامه علوم و فناوری فضایی, 2010 Weight optimization is one of important parameters in space structure design. Size optimization is usually performed using gradient or genetic algorithm. Gradient algorithm is based on derivation of objective function and constraints of problem.
A. Vafaeesefat, S. H. Tabatabai
doaj
Genetic Optimization of Keywords Subset in the Classification Analysis of Texts Authorship [PDF]
arXiv, 2012 The genetic selection of keywords set, the text frequencies of which are considered as attributes in text classification analysis, has been analyzed. The genetic optimization was performed on a set of words, which is the fraction of the frequency dictionary with given frequency limits.
arxiv
, 2022 Hybrid optimization methods have known significant interest in recent years and are being growingly used to solve complex problems in science and engineering. For instance, the famous evolutionary Genetic Algorithm can integrate other techniques within its framework to produce a hybrid global algorithm that takes advantages of that combination and ...
openaire +2 more sources
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Boundary Evolution Algorithm for SAT-NP [PDF]
arXiv, 2018 A boundary evolution Algorithm (BEA) is proposed by simultaneously taking into account the bottom and the high-level crossover and mutation, ie., the boundary of the hierarchical genetic algorithm. Operators and optimal individuals based on optional annealing are designed.
arxiv
Genetic and evolutionary algorithms come of age [PDF]
, 1994 David E. Goldberg
openalex +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Genetic algorithms for protein tertiary structure prediction [PDF]
, 1993 Steffen Schulze-Kremer
openalex +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source