Results 111 to 120 of about 7,593,248 (327)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
A Comparison between Memetic algorithm and Genetic algorithm for the cryptanalysis of Simplified Data Encryption Standard algorithm [PDF]
International Journal of Network Security & Its Applications 1.1
(2009) 34-42, 2010 Genetic algorithms are a population-based Meta heuristics. They have been successfully applied to many optimization problems. However, premature convergence is an inherent characteristic of such classical genetic algorithms that makes them incapable of searching numerous solutions of the problem domain.
arxiv
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
The degeneracy of the genetic code and Hadamard matrices [PDF]
arXiv, 2008 The matrix form of the presentation of the genetic code is described as the cognitive form to analyze structures of the genetic code. A similar matrix form is utilized in the theory of signal processing. The Kronecker family of the genetic matrices is investigated, which is based on the genetic matrix [C A; U G], where C, A, U, G are the letters of the
arxiv
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Searching the landscape of flux vacua with genetic algorithms
Journal of High Energy Physics, 2019 In this paper, we employ genetic algorithms to explore the landscape of type IIB flux vacua. We show that genetic algorithms can efficiently scan the landscape for viable solutions satisfying various criteria. More specifically, we consider a symmetric T
Alex Cole, Andreas Schachner, Gary Shiu
doaj +1 more source
A Spectral Graph Approach to Discovering Genetic Ancestry [PDF]
Annals of Applied Statistics, 4(1), 179-201, 2010, 2009 Mapping human genetic variation is fundamentally interesting in fields such as anthropology and forensic inference. At the same time patterns of genetic diversity confound efforts to determine the genetic basis of complex disease. Due to technological advances it is now possible to measure hundreds of thousands of genetic variants per individual across
arxiv
Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
Optimal Design of a Cam Mechanism with Translating Flat-Face Follower using Genetic Algorithm [PDF]
Tribology in Industry, 2013 The optimum design of a cam mechanism is a time consuming task, due to the numerous alternatives considerations. In the present work, the problem of design parameters optimization of a cam mechanism with translating flat - face follower is investigated ...
I. Tsiafis +3 more
doaj
Results of Evolution Supervised by Genetic Algorithms [PDF]
arXiv, 2010 A series of results of evolution supervised by genetic algorithms with interest to agricultural and horticultural fields are reviewed. New obtained original results from the use of genetic algorithms on structure-activity relationships are reported.
arxiv